| HPLC法测定盐酸奈必洛尔片中主药的含量 |
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| 引用本文： | 邵珠民,孟庆华,王福贵,姬怀雪,赖冉,杜森.HPLC法测定盐酸奈必洛尔片中主药的含量[J].中国药房,2010(33):3152-3153. |
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| 作者姓名： | 邵珠民 孟庆华 王福贵 姬怀雪 赖冉 杜森 |
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| 作者单位： | [1]徐州医学院附属医院药剂科,徐州市221002 [2]徐州师范大学化工学院,徐州市221116 [3]徐州医学院,徐州市221002 |
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| 摘 要： | 目的:建立以高效液相色谱法测定盐酸奈必洛尔片中主药含量的方法。方法:色谱柱为XTerra RP18,流动相为甲醇-0.03mo·lL-1磷酸二氢钾(0.68∶0.32),流速为1.0mL·min-1,检测波长为280nm,柱温为30℃。结果:盐酸奈必洛尔检测浓度线性范围为15.24～55.88μg·mL-1(r=0.9999,n=5);平均回收率为100.3%,RSD=0.74%(n=6)。结论:本方法简便、灵敏、准确,可用于盐酸奈必洛尔片中主药的含量测定。
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| 关 键 词： | 盐酸奈必洛尔片 高效液相色谱法 含量测定 |
Content Determination of Main Component in Nebivolol Hydrochloride Tablets by HPLC |
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| SHAO Zhu-min,WANG Fu-gui,JI Huai-xue,LAI RanDept. of Pharmacy,The Affiliated Hospital of Xuzhou Medical College,Xuzhou,China MENG Qing-huaCollege of Chemical Technology,Xuzhou Normal University,Xuzhou,China DU Sen.Content Determination of Main Component in Nebivolol Hydrochloride Tablets by HPLC[J].China Pharmacy,2010(33):3152-3153. |
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| Authors: | SHAO Zhu-min WANG Fu-gui JI Huai-xue LAI RanDept of Pharmacy The Affiliated Hospital of Xuzhou Medical College Xuzhou China MENG Qing-huaCollege of Chemical Technology Xuzhou Normal University Xuzhou China DU Sen |
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| Institution: | SHAO Zhu-min, WANG Fu-gui,JI Huai-xue, LAI Ran(Dept. of Pharmacy, The Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002,China) MENG Qing-hua(College of Chemical Technology, Xuzhou Normal University, Xuzhou 221116,China ) DU Sen (Xuzhou Medical College,Xuzhou 221002,China ) |
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| Abstract: | OBJECTIVE：To establish an HPLC method for determination the content of main component in nebivolol hydrochloride tablets. METHODS：The XTerra RP18 column was used, the mobile phase consisted of methanol-0.03 mol·L-1 KH2PO4 solution（0.68 ∶ 0.32） at a flow rate of 1.0 mL·min-1,the detection wavelength was 280 nm, and the column temperature was 30 ℃. RESULTS：The linear range of nebivolol hydrochloride was 15.24～55.88 ？g·mL-1（r=0.999 9,n=5）. The average recovery rate was 100.3% and RSD was 0.74% （n=6）.CONCLUSION：The method is simple, sensitive, accurate and can be used for the determination of nebivolol hydrochloride tablets. |
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| Keywords: | Nebivolol hydrochloride tablets HPLC Content determination |
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