雷贝拉唑对非糜烂性反流病症状和心理的影响

目的:探讨雷贝拉唑对非糜烂性反流病(NERD)症状及心理因素的影响。方法:对符合入选标准的169例NERD患者进行胃食管反流病诊断问卷(GerdQ)调查,仔细询问患者近1周的胃食管反流相关症状并进行症状记分。结果:159例患者完成治疗,治疗前非糜烂性反流病的GerdQ评分为(10.44±1.62)分,Zung自评焦虑量表(SAS)评分为(47.11±10.92)分,自评抑郁量表(SDS)评分为(44.59±11.2)分。治疗1周后,反流相关症状明显缓解,SAS、SDS评分均明显低于治疗前,4周后降低更明显,差异有统计学(P<0.05)。结论:非糜烂性反流病存在焦虑抑郁状态,使用雷贝拉唑治疗非糜烂性反流病可改善患者的症状和心理因素。

Effects of Rabeprazole on Symptoms and Psychological Status in Patients with Non-erosive Reflux Disease

OBJECTIVE：To investigate the effect of rabeprazole on symptoms and psychological status of patients with non-erosive reflux disease （NERD）.METHODS：GerdQ questionnaire survey was performed in 169 patients who accorded with diagnosis criteria to investigate relevant symptoms of gastroesophageal reflux disease in 1 week.Symptoms scores were carried out according to the occurrence frequency of heartburn,gastroesophageal reflux,nausea and epigastric pain,etc.RESULTS：159 NERD patients completed 4 weeks of treatment.GerdQ score was （10.44±1.62） and SAS score （47.11±10.92）,SDS score （44.59±11.2） before treatment.After 1 week of treatment,relevant clinical symptoms relieved obviously,and SAS score and SDS score were lower than before treatment strikingly.The decrease of SAS score and SDS score were more significant after 4 weeks of treatment.There were statistical significance （P0.05）.CONCLUSION：NERD patients suffer from anxiety and depression.Rabeprazole can improve symptoms and psychological factors in NERD patients.