前列地尔注射液辅助治疗老年糖尿病的疗效观察

目的:观察前列地尔注射液用于老年糖尿病辅助治疗时的临床疗效及安全性。方法:将符合纳入标准的病例采用随机分组平行对照法,分为观察组和对照组,各34例。对照组给予降糖药物(包括胰岛素)及饮食控制、适当体育锻炼等综合治疗,观察组在上述治疗的基础上加用前列地尔注射液,治疗15 d;观察对比2组治疗后的血小板聚集试验、甲皱微循环及安全性指标变化情况。结果:治疗后2组比较,观察组血小板聚集明显抑制(P<0.05);甲皱微循环流态积分、管周积分及总积分值显著下降(P<0.05)。结论:前列地尔注射液用于老年糖尿病辅助治疗时短期内有较好的疗效和安全性,其作用机制可能与改善微循环、降低血小板聚集率等有关。

Efficacy Observation of Adjunctive Therapy of Alprostadil Injection for Diabetes in the Elderly

OBJECTIVE：To observe the clinical efficacy and safety of adjunct therapy of alprostadil injection for diabetes in the elderly.METHODS：Patients conforming to inclusion criteria were randomly divided into observation group and control group（n=34.） Observation group were additionally treated with PGE1 injection for 15 days.Nail fold microcirculation examination was performed.Platelet aggregation and index of safety in two groups were observed before and after treatments.RESULTS：Compared with control group,platelet aggregation was inhibited significantly in observation group（P0.05）;score of nail fold microcirculation,score of perivascular conditions and total score value were significantly decreased after treatment（P0.05.） CONCLUSION： PGE1 injection is safe and effective in the treatment of diabetes in the elderly.The effective mechanism may be associated with the improvement of microcirculation and inhibition of platelet aggregation.