我院238例药品不良反应报告分析

目的:分析我院药品不良反应(ADR)发生的相关因素,以降低外在因素引发ADR的发生率,促进临床合理用药。方法:对我院2008年1月1日～2009年12月25日经ADR监测中心审核的238例ADR报告,进行回顾性统计、分析。结果:238例ADR中,>60岁老年患者达59例(占24.79%);静脉给药引发的ADR最多,有230例(占89.49%);涉及用药品种以抗微生物药为主,有161例(占62.65%);累及器官或系统以皮肤及其附件损害最为常见,有167例(占63.74%);由不合理用药引发的为15例(占6.30%)。结论:临床应深入开展ADR监测工作,促进合理用药,降低ADR发生率。

Analysis of 238 Cases of Adverse Drug Reaction in Our Hospital

OBJECTIVE：To explore the factors of adverse drug reaction（ADR）reported in our hospital in order to reduce the incidence of ADR induced by external factors and promote rational use of drugs.METHODS：238 cases of ADR reports collected by ADR Monitoring Center in our hospital from Jan.1st,2008 to Dec.25th,2009 were analyzed retrospectively.RESULTS：Of 238 ADR cases,59 cases occurred in senile patients over 60 years old（24.79%）;230 ADR cases were resulted from intravenous administration（89.49%）;161 ADR cases were mainly given antibiotics（62.65%）.Main clinical manifestations in 167 cases were lesion of skin and its appendants（63.74%）.15 ADR cases were caused by irrational use of drugs（6.30%）.CONCLUSION：Great importance should be attached to ADR monitoring to promote rational use of drugs and reduce the incidence of ADR.