| 5-硝基水杨酸合成新工艺 |
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| 引用本文： | 王萍萍,陆杨,李新阳.5-硝基水杨酸合成新工艺[J].中国药房,2010(41):3877-3878. |
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| 作者姓名： | 王萍萍 陆杨 李新阳 |
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| 作者单位： | [1]杭州第四医院,杭州市310002 [2]浙江建德建业有机化工有限公司,建德市311611 |
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| 摘 要： | 目的:采用新方法合成5-硝基水杨酸。方法:以水杨酸为原料,采用硝酸脲/硫酸为硝化试剂,反应得到5-硝基水杨酸以收率为指标考察了反应条件包括硝酸脲/水杨酸物料配比、反应温度、反应时间对反应的影响。结果:得到适合的反应条件为硝酸脲/水杨酸(摩尔比)=1.2:1,反应温度25℃,反应时间6 h,收率为86.4%。结论:新方法收率较高,反应条件温和,适合工业化生产。
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| 关 键 词： | 5-硝基水杨酸 合成工艺 硝化试剂 收率 |
Improved Synthesis Technology of 5-nitrosalicylic Acid |
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| WANG Ping-ping,LU Yang,LI Xin-yang.Improved Synthesis Technology of 5-nitrosalicylic Acid[J].China Pharmacy,2010(41):3877-3878. |
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| Authors: | WANG Ping-ping LU Yang LI Xin-yang |
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| Institution: | 1.Hangzhou Fourth Hospital,Hangzhou 310002,China;2.Zhejiang Jiangde Jianye Chemical Co.,Ltd.,Jiande 311611,China) |
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| Abstract: | OBJECTIVE：To synthesize 5-nitrosalicylic acid by a new method.METHODS：5-nitrosalicylic acid was synthesized using salicylic acid as raw material and urea nitrate/sulphuric acid as nitrating agent.The influences of material ratio,reaction temperature and reaction time were investigated with yield of nitration as index.RESULTS：Optimal reaction condition was as follows：ration of urea nitrate to salicylic acid（mole ratio） was 1.2：1;reaction temperature was 25 ℃ and reaction time was 6 h.The yield of nitration was 86.4%.CONCLUSION：The method is characterized with high yield and moderate reaction condition.It is suitable for industrial production. |
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| Keywords: | 5-nitrosalicylic acid Synthesis technology Nitrating agent Yield |
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