不同剂量还原型谷胱甘肽在急性髓系白血病化疗中对肝功能保护作用的临床观察

目的:观察不同剂量还原型谷胱甘肽在急性髓系白血病化疗中对肝功能保护作用的临床疗效。方法:采用前瞻性研究,将72例应用还原型谷胱甘肽的急性髓系白血病患者分为A组和B组,A组剂量为1.2g·d-1,B组剂量为2.4g·d-1,化疗前2d开始使用,至化疗结束后1周复查肝功能,发现肝功能异常后继续使用2周。结果:B组患者化疗后1周及2周肝功能损害发生率较A组明显降低(P<0.05)。2组在化疗后第1周和第2周不良反应率低,未见明显的食欲不振、恶心、呕吐等消化道症状。结论:提高还原型谷胱甘肽的剂量可有效预防和治疗化疗后肝功能损害,不良反应较轻。

Protection Effects of Different Dosage of Reduced Glutathione on Liver Function in Acute Myeloid Leukemia Patients Undergoing Chemotherapy

OBJECTIVE：To discuss the protection effects of different dosage of reduced glutathione on liver function in acute myeloid leukemia（AML） patients undergoing chemotherapy.METHODS：In prospective study,72 AML patients were divided into group A and group B according to the dosage of reduced glutathione.Reduced glutathione were given to group A（1.2 g·d-1） and group B（2.4 g·d-1） 2 days before chemotherapy.Liver functions of patients were rechecked 1 week after chemotherapy.Another 2 weeks of treatment was given to patients with liver function disorder.RESULTS：1 week or 2 weeks after chemotherapy the incidence of liver function impairment in group B was decreased significantly,compared with group A（P0.05）;1 week or 2 weeks after chemotherapy,2 groups showed low incidence of ADR,no obvious gastrointestinal tract symptom,such as anorexia,nausea and vomiting.CONCLUSION：High dose of reduced glutathione can effectively prevent and treat liver function impairment after chemotherapy with mild ADR.