| 抗口腔溃疡炎膜剂的制备及质量控制 |
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| 引用本文： | 何心,王帆,杨大伟,孙照英,张闯.抗口腔溃疡炎膜剂的制备及质量控制[J].中国药房,2010(17):1582-1583. |
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| 作者姓名： | 何心 王帆 杨大伟 孙照英 张闯 |
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| 作者单位： | [1]黑龙江省医院药学部,哈尔滨市150036 [2]黑龙江中医药大学,哈尔滨市150040 |
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| 基金项目： | 哈尔滨市科技创新人才研究专项基金资助项目（2008RFXQS035） |
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| 摘 要： | 目的:制备抗口腔溃疡炎膜剂并建立其质量标准。方法:先制备含药胶浆和空白胶浆再制备成复合膜剂;应用高效液相色谱法对制剂中靛玉红进行定量分析。结果:制备的膜剂外观均一性良好,各项检测指标符合《中国药典》相关规定;靛玉红检测浓度线性范围为0.8～6.4μg·mL-(1r=0.9998);平均回收率为100.65%(RSD=1.07%,n=6)。结论:所制膜剂处方合理、制备方法简单可行,含量测定方法准确可靠。
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| 关 键 词： | 抗口腔溃疡炎膜剂 靛玉红 制备 质量控制 高效液相色谱法 |
Preparation and Quality Control of Anti-inflammatory Dental Ulcer Film |
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| HE XinDept. of Pharmacy,Heilongjiang Provincial Hospital,Harbin,China WANG Fan,YANG Da-wei,SUN Zhao-ying,ZHANG Chuang.Preparation and Quality Control of Anti-inflammatory Dental Ulcer Film[J].China Pharmacy,2010(17):1582-1583. |
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| Authors: | HE XinDept of Pharmacy Heilongjiang Provincial Hospital Harbin China WANG Fan YANG Da-wei SUN Zhao-ying ZHANG Chuang |
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| Institution: | (Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China) |
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| Abstract: | OBJECTIVE： To prepare anti-inflammatory dental ulcer film and establish its quality standard. METHODS： Drug-containing mortar and blank mortar were prepared to prepare compound film agent. HPLC was used to the quantitative analysis of indirubin. RESULTS： The preparation had well appearance and its detection of index was up to the standard stated in Chinese Pharmacopeia. The linear range of indirubin was 0.8～6.4 μg·mL-1 （r=0.999 8） with an average recovery rate of 100.65% （RSD=1.07%,n=6）. CONCLUSION： The formula of preparation is reasonable, the preparation method is simple and applicable and determination method is accurate and reliable. |
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| Keywords: | Anti-inflammatory dental ulcer film Indirubin Preparation Quality Control HPLC method |
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