血液肿瘤患儿脓毒症病原菌及其药物敏感性分析

目的：了解2006～2008年血液肿瘤住院患儿脓毒症病原菌及其耐药情况。方法：药敏试验采用纸片扩散法。结果：革兰阳性球菌107株（64.8%）,耐甲氧西林凝固酶阴性葡萄球菌最常见,未检出对糖肽类和利奈唑胺耐药菌株;革兰阴性杆菌57株（34.5%）,大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌最常见,未检测出对碳青霉烯类耐药菌株;真菌1株。结论：血液肿瘤患儿脓毒症革兰阳性菌占优势,回顾性分析是经验用药的依据。

Analysis on Septic Pathogen Distribution in Children with Neoplastic Hematologic Disorder and Drug Susceptibility

OBJECTIVE：To investigate septic pathogen distribution in children with neoplastic hematologic disorder and situation of antibiotic resistance.METHODS：Disc diffusion method was adopted to detect drug sensitivity.RESULTS：107 gram-positive bacteria（64.8%）were found.The most common strains were methicillin-resistant coagulase negative staphylococcus.Vancomycin and teicoplanin drug-resistant strain was not found.57 strains were gram-negative bacteria（34.5%）.The most common strains were E.coli,K.pneumonia and Pseudomonas aeruginosa.Carbopenem drug-resistance strain was not found.Only one fungus was found.CONCLUSION：The dominant pathogen in children with neoplastic hematologic disorder is gram-positive bacteria and retrospective analysis is the basis of empirical antibiotic treatment.