玉米须提取物对胆汁淤积性肝病的改善作用研究

目的:研究玉米须提取物对胆汁淤积性肝病的改善作用。方法:通过胆管结扎复制大鼠急性胆汁淤积性肝损伤模型,异硫氰酸-α-萘酯(ANIT)复制大鼠胆汁淤积性肝病模型。以6.2、3.1g·kg-1剂量玉米须提取物给药5d,测定血清总胆红素(TBIL)、直接胆红素(DBIL)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆汁酸(TBA)等生化指标的含量和胆汁流量。结果:玉米须提取物能降低大鼠ANIT诱导性胆汁淤积性肝病模型血清DBIL、ALT、TBA含量(P<0.01或P<0.05),增加胆汁流量与流速(P<0.01或P<0.05);降低大鼠胆管结扎致急性胆汁淤积性肝损伤模型血清DBIL、ALT含量(P<0.05)。结论:玉米须提取物对胆汁淤积性肝病有一定的改善作用,对肝内胆汁淤积性肝病改善作用明显,对胆管阻塞性肝外胆汁淤积性肝病改善作用较弱。

Study on Improvement of Zea mays Extract on Cholestatic Liver Diseases

OBJECTIVE：To study the improvement of Zea mays extract on cholestatic liver diseases.METHODS： Acute cholestatic liver injury model of rat was induced by bile duct ligation and cholestatic liver model of rats was established by ANIT.Model rats were given 6.2 g·kg-1 and 3.1 g·kg-1 dose of Z.mays extract for 5 days.The content of TBIL,DBIL,ALT,AST and TBA in serum and the secretion of bile were determined.RESULTS： The corn stigma extract decreased the content of DBIL,ALT and TBA in serum of ANIT-inducing cholestatic liver model,and increased the flow and speed of bile （P0.01 or P0.05）.The Z.mays extract decreased the content of DBIL and ALT in acute cholestatic liver injury model induced by bile duct ligation （P0.05）.CONCLUSION： The Z.mays extract can improve cholestatic liver diseases,especially intrahepatic cholestatic liver diseases but have less effect on extrahepatic cholestatic liver diseases induced by bile duct occlusion.