| 乳痛宁颗粒成型工艺研究 |
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| 引用本文： | 张茂慧,赵军,李献林,王建华.乳痛宁颗粒成型工艺研究[J].中国药房,2010(31):2914-2915. |
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| 作者姓名： | 张茂慧 赵军 李献林 王建华 |
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| 作者单位： | 新疆医科大学第一附属医院药剂科,乌鲁木齐市830054 |
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| 摘 要： | 目的:研究乳痛宁颗粒的最佳制粒处方组成。方法:以颗粒吸湿百分率、成型率和溶化率为指标,筛选颗粒最佳辅料与配比。结果:处方最佳组成为1份浸膏粉加1.5份蔗糖。所制颗粒吸湿性小、成型率高、溶解性好、成本低,临界相对湿度约为65%。结论:本研究可为乳痛宁颗粒制剂处方组成的确定及生产环境的控制提供理论依据。
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| 关 键 词： | 乳痛宁颗粒 成型工艺 临界相对湿度 |
Study on Formulation Process of Rutongning Granule |
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| ZHANG Mao-hui,ZHAO Jun,LI Xian-lin,WANG Jian-hua.Study on Formulation Process of Rutongning Granule[J].China Pharmacy,2010(31):2914-2915. |
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| Authors: | ZHANG Mao-hui ZHAO Jun LI Xian-lin WANG Jian-hua |
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| Institution: | (Dept. of Pharmacy, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China) |
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| Abstract: | OBJECTIVE： To study optimal formulation process of Rutongning granule. METHODS： The ratio of main components to excipients was optimized with hygroscopicity,granulation and dissolubility index. RESULTS： The optimal ratio of extract powder to saccharose was 1 ∶ 1.5. The made granules were characterized with low hygroscopicity, high granulation,high dissolubility and low cost. And its critical relative humidity was 65%. CONCLUSION： The study provides theory evidence for formulation process of Rutongning granule and the control of production environment. |
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| Keywords: | Rutongning granule Formulation process Critical relative humidity |
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