| 伊曲康唑脂质体体外抗真菌作用研究 |
| |
| 引用本文： | 纪宏宇,魏华,刘红梅,唐景玲,董迪,宋笑丹,吴琳华.伊曲康唑脂质体体外抗真菌作用研究[J].中国药房,2010(41):3869-3871. |
| |
| 作者姓名： | 纪宏宇 魏华 刘红梅 唐景玲 董迪 宋笑丹 吴琳华 |
| |
| 作者单位： | [1]哈尔滨医科大学附属第二医院药学部,哈尔滨市150086 [2]黑龙江省高校重点实验室,哈尔滨市150086 [3]哈尔滨医科大学附属第一医院药学部,哈尔滨市150001 [4]哈尔滨医科大学药学院,哈尔滨市150086 |
| |
| 基金项目： | 黑龙江省科技厅重点课题（GB06C307） |
| |
| 摘 要： | 目的:研究伊曲康唑脂质体体外抗深部真菌作用。方法:测定伊曲康唑脂质体对白色念珠菌、克柔念珠菌、光滑念珠菌、近平滑念珠菌、热带念珠菌等5种临床常用深部真菌的最小抑菌浓度(MIC)和最小杀菌浓度(MBC),采用平皿菌落计数法进行菌落计数,制备克柔念珠菌、近平滑念珠菌的菌落数-时间曲线,并与伊曲康唑注射液的结果进行比较。结果:与伊曲康唑注射液比较,伊曲康唑脂质体对5种深部真菌的MIC、MBC基本一致,对克柔念珠菌、近平滑念珠菌的菌落数-时间曲线基本一致。结论:伊曲康唑脂质体与伊曲康唑注射液对5种深部真菌具有相似的体外抗真菌作用。
|
| 关 键 词： | 伊曲康唑 脂质体 最小抑菌浓度 最小杀菌浓度 菌落数-时间曲线 |
In Vitro Antifungal Activity of Itraconazole Liposome |
| |
| JI Hong-yu,LIU Hong-mei,DONG Di,WU Lin-hua.In Vitro Antifungal Activity of Itraconazole Liposome[J].China Pharmacy,2010(41):3869-3871. |
| |
| Authors: | JI Hong-yu LIU Hong-mei DONG Di WU Lin-hua |
| |
| Institution: | , JI Hong-yu,LIU Hong-mei,WU Lin-hua, WEI Hua,SONG Xiao-dan, TANG Jing-ling(1.Dept.of Pharmacy,The Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China;2.Key Laboratory of College and University of Heilongjiang Province,Harbin 150086,China;3.Dept.of Pharmacy,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China;4.College of Pharmacy,Harbin Medical University,Harbin 150086,China) |
| |
| Abstract: | OBJECTIVE：To study the antifungal activity of Itraconazole liposome in vitro.METHODS：The minimal inhibitory concentration（MIC） and the minimal bactericidal concentration（MBC） of Itraconazole liposome against 5 kinds of deep fungus（Candida albicans,Candida krusei,Candida glabrata,Candida parapsilosis,Oidium tropioale） were determined.The number of colony was calculated by plate counting method.Colony number-time curves of Itraconazole liposome against Candida krusei and Candida parapsilosis were measured and compared with that of Itraconazole injections.RESULTS：MIC,MBC and colony number-time curves of Itraconazole liposome against 5 kinds of deep fungus were similar to those of Itraconazole injection in experiments.CONCLUSION：The in vitro antifungal activity of Itraconazole liposome against 5 kinds of deep fungus is similar to that of Itraconazole injection. |
| |
| Keywords: | Itraconazole Liposomes Minimal inhibitory concentration Minimal bactericidal concentration Colony number-time curves |
| 本文献已被 维普 等数据库收录！ |
|
