我院2008年药品不良反应报告分析

目的:了解我院药品不良反应(ADR)发生的特点及规律。方法:收集我院2008年上报合格的535例ADR报告,并进行统计和分析。结果:ADR发生率男性与女性之比为1.10∶1;≥60岁老年人ADR发生率最高,有197例(36.82%)。静脉给药途径引发的ADR占80.37%(430例)。引发ADR最常见的是抗微生物药,有254例(占47.48%);其次是中药制剂,有75例(占14.02%)。ADR临床表现以皮肤及其附件损害最为常见,有212例(占39.63%);其次是消化系统损害,有164例(占30.65%)。绝大多数ADR转归良好。结论:应不断加强我院医、药、护人员ADR监测工作的宣传、教育与指导,确保临床用药安全、有效、经济。

Analysis on ADR Case Reports of Our Hospital in 2008

OBJECTIVE：To probe into the characteristics and regularity of adverse drug reactions（ADR）cases occurred in our hospital.METHODS：535 ADR cases reported in our hospital in 2008 were collected and analyzed statistically.RESULTS：In the incidence of 535 ADR cases,the ratio of male to female were 1.10∶1.Patients over the age of 60 years showed the highest incidence,accounted for 36.82%（n=197）.430 ADR cases were induced by intravenous route（80.37%）;254 cases were induced by antimicrobials（47.48%）,followed by TCM preparations（n=75,14.02%）.The ADR were chiefly manifested as lesion of skin and its appendants in 212 cases（39.63%）,followed by 164 cases of lesion of digestive system（30.65%）.Most ADR cases had a favorable prognosis.CONCLUSION：It should be strengthened to offer education and guidance of ADR monitoring for medical staff so as to make sure the safety,effectiveness and convenience of drug use in the clinic.