复方丹参片对环孢素A肾毒性的拮抗作用研究

目的:探讨复方丹参对环孢素A(CsA)所致慢性肾毒性的拮抗作用。方法:对54例肾移植手术的患者进行分析,根据应用复方丹参的剂量不同,将其分为3组:CsA+复方丹参高剂量组、CsA+复方丹参低剂量组(试验组)、CsA对照组(对照组)。监测3组的CsA血药浓度、血肌酐、尿素氮浓度、24h尿量、24h尿蛋白量以及比较组织形态学及血流参数,并对各组间的差异进行统计学分析。结果:应用CsA+复方丹参高剂量组方案的患者与应用其他方案的患者相比血肌酐、尿素氮浓度、24h尿蛋白量明显降低,24h尿量增加,3组比较均有显著性差异(P<0.01或P<0.05);CsA血药浓度3组比较差异无统计学意义(P>0.05)。肾内血流丰富,肾动脉阻力指数明显增加。结论:应用CsA+复方丹参高剂量组方案能更好的拮抗CsA的肾毒性。

Antagonistic Effect of Compound Danshen Tablets on Nephrotoxicity Induced by Cyclosporine A

OBJECTIVE： To investigate the antagonistic effect of Salvia miltiorrhiza on cyclosporine A （CsA）-induced chronic nephrotoxicity. METHODS： 54 patients underwent renal transplantation were divided into 3 groups according to dosage of salvia miltiorrhiza： CsA＋high-dose of salvia miltiorrhiza group, CsA＋loe-dose of salvia miltiorrhiza group （trial group） and CsA control group （control group）. Plasma concentration of CsA, serum creatinine （Scr）, blood urea nitrogen （Bun）, 24 h urines and 24 h urinary protein were recorded. The parameters of morphology and hemodynamics were compared among 3 groups. The differences of index among 3 groups were analyzed statistically. RESULTS： The level of Scr, Bun and 24 h urinary protein in CsA＋high-dose of salvia miltiorrhiza group were decreased significantly while 24 h urines was increased, compared with other 2 groups. There was significant difference among 3 groups （P〈0.01 or P〈0.05）. There was no significant difference in plasma concentration of CsA among 3 groups （P〉0.05）. The intrarenal blood flow and renal arterial resistance index were increased significantly in CsA＋high-dose of salvia miltiorrhiza group. CONCLUSION： High-dose of salvia miltiorrhiza combined with CsA can reduce the CsA-induced nephrotoxicity perfently.