静脉尿路造影检查前不同时间口服复方聚乙二醇电解质散的效果比较

目的:探讨静脉尿路造影(IVU)检查前患者何时口服复方聚乙二醇电解质散较好。方法:将380例拟行IVU检查的患者随机分为A、B组,A组190例,检查前4h口服复方聚乙二醇电解质散;B组190例,检查前一天晚饭后2h口服同样剂量。观察2组服药后的排便情况、不良反应及X线摄片质量。结果:不良反应发生率A组为6.3%(12/190),B组为9.5%(18/190),2组间差异无统计学意义(P>0.05);A组平均首次排便时间、腹泻持续时间及排便次数分别为(21.4±7.4)min、(138.4±29.3)min和(4.7±2.3)次,B组平均首次排便时间、腹泻持续时间及排便次数分别为(20.9±9.8)min、(133.8±36.5)min和(4.4±2.1)次,2组差异均无统计学意义(P>0.05);X线摄片质量良好率A组为73.7%(140/190),B组为57.9%(110/190),2组间差异有统计学意义(P<0.05)。结论:复方聚乙二醇电解质散用于IVU检查前的肠道清洁准备,不良反应少、肠道清洁效果佳,X线摄片质量好,检查前4h开始服更理想。

Comparison of Clinical Efficacy of Oral Administration of PEG-ELS at Different Time before Intravenous Urography

OBJECTIVE：To probe into the optimal medication time of poly（ethylene glycol）electrolyte powder（PEG-ELS） before intravenous urography（IVU）. METHODS：380 patients as candidates for IVU were randomized into group A and group B （n=190）. Group A were given oral dose of PEG-ELS at 4 h before examination and group B were given medicine at 2 h after supper the night before checking. The quality of X radiogram and adverse drug reactions of the patients as well as defecation time and times were observed and compared. RESULTS：The incidence of adverse drug reactions was 6.3%（12/190）in group A and 9.5% （18/190）in group B,and there was no statistical significance in difference between two groups（P0.05）. The average initial defecation time,the average duration of defecation and the average times of defecation of group A were（21.4±7.4）min,（138.4±29.3） min and（4.7±2.3）times respectively and those of group B’s were（20.9±9.8）min,（133.8±36.5）min and（4.4±2.1）times respectively. There was no statistical significance in difference between two groups（P0.05）. The rate of favorable X radiogram was 73.7%（140/190）in group A and 57.9%（110/190）in group B. There was statistical significance in difference between two groups （P0.05）. CONCLUSION：Oral administration of PEG-ELS can achieve good effect of intestine cleaning and favorable X radiogram at 4 h before IVU with less adverse drug reaction.