伊托必利对比多潘立酮治疗功能性消化不良的Meta分析

目的:系统评价伊托必利对比多潘立酮治疗功能性消化不良(FD)的疗效和安全性。方法:计算机检索PubMed、EMBASE、SCI、CBM、CNKI、VIP、万方数据库及Cochrane图书馆,补充手工检索,对纳入伊托必利对比多潘立酮治疗FD的随机对照试验(RCT)进行方法学质量评价和Meta分析。结果:共纳入18个RCT,B级文献11篇,C级文献7篇。总有效率及恶心、上腹胀、嗳气、呕吐、上腹疼痛、反酸的缓解率伊托必利组均高于多潘立酮组,但差异无统计学意义;不良反应发生率伊托必利组低于多潘立酮组,但差异无统计学意义;早饱、厌食的缓解率伊托必利组高于多潘立酮组,且差异有统计学意义。结论:基于当前证据,伊托必利治疗FD疗效优于多潘立酮,期待高质量研究证实。

Meta-analysis on Itopride vs. Domperidone in the Treatment of Functional Dyspepsia

OBJECTIVE：To review the curative efficacy and safety of itopride vs. domperidone in the treatment of functional dyspepsia（FD）. METHODS：Randomized controlled trails（RCTs）of itopride vs. domperidone in the treatment of FD were enrolled and retrieved from Cochrane Library,PubMed,EMBASE,SCI,CBM,CNKI,VIP and Wanfang Database. Other retrieval was carried out by hand. Methodological quality evaluation and meta-analysis of RCTs were carried out. RESULTS：Of total 18 RCTs enrolled,11 RCTs were graded B and 7 RCTs graded C. Itopride group were superior to domperidone group in respect of total response rate,the relief rate of nausea,abdominal distention,belching,vomiting,epigastric pain and sour regurgitation. There was no statistical significance. The incidence of ADR in itopride group was lower than in domperidone group. There was no statistical significance in difference between two groups. The relief rate of anorexia and early satiety in itopride group were superior to domperidone group. Statistical significance was noted in difference between two groups. CONCLUSION：Recent study shows itopride has better effect than domperidone on FD,which should be confirmed by high quality study.