还原型谷胱甘肽治疗抗结核药致药物性肝损害的疗效观察

目的:观察还原型谷胱甘肽治疗抗结核药致药物性肝损害的疗效。方法:89例初治菌阳性肺结核患者随机分为治疗组和对照组,均应用"2H3R3Z3E3(S3/)4H3R3"方案抗结核治疗,对照组采用常规护肝治疗,治疗组在对照组基础上加用还原型谷胱甘肽。结果:治疗组在肝功能指标丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBIL)改善方面均优于对照组(P<0.05);总有效率治疗组与对照组分别为89.7%、67.5%(P<0.01)。结论:还原型谷胱甘肽可显著改善初治菌阳性肺结核患者的抗结核药致药物性肝损害。

Clinical Efficacy of Reduced Glutathione in the Treatment of Drug-induced Liver Injury Caused by Anti-tuberculosis Drug

OBJECTIVE：To observe clinical efficacy of reduced glutathione in the treatment of druginduced liver injury caused by antituberculosis drug.METHODS：89 cases of newly diagnosed pulmonary tuberculosis were randomly divided into treatment group（n=49）and control group（n=40.） Both groups were given 2H3R3Z3E3（S3/）4H3R3 antituberculosis therapy regimen and conventional liver protection therapy.Treatment group were additionally treated with reduced glutathione.RESULTS： The improvement of liver function index in treatment group,such as alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,total bilirubin（TBIL）,were better than in control group.There was significant difference between two groups（P0.05）.Total response rate were 89.7% for treatment group and 67.5% for control group,there was significant difference between two groups（P0.01.） CONCLUSION：Reduced glutathione can significantly improve the druginduced liver injury caused by antituberculosis drug.