| 双白片质量标准研究 |
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| 引用本文： | 杨婉花,郝晓静,李娟,姚英,施惠娟,陈冰.双白片质量标准研究[J].中国药房,2010(27):2549-2551. |
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| 作者姓名： | 杨婉花 郝晓静 李娟 姚英 施惠娟 陈冰 |
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| 作者单位： | [1]上海交通大学医学院附属瑞金医院药剂科,上海市200025 [2]上海中医药大学,上海市200032 [3]上海上联药业有限公司,上海市201703 |
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| 基金项目： | 上海市科研计划项目课题（08ZR141400） |
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| 摘 要： | 目的:建立双白片的质量标准。方法:采用薄层色谱(TLC)法鉴别双白片中黄芪、刺五加和芍药;采用高效液相色谱(HPLC)法测定双白片中芍药苷的含量。结果:双白片中黄芪、刺五加及芍药的TLC分别在与对照品色谱对应的位置上显相同颜色的斑点,专属性好。芍药苷进样浓度在3.20～64.00μg·mL-1范围内与峰面积积分值呈良好的线性关系(r=0.9993);平均回收率为99.12%,RSD=1.18%(n=6)。结论:所建标准可用于双白片的质量控制。
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| 关 键 词： | 双白片 薄层色谱法 高效液相色谱法 质量标准 |
Study on Quality Standard of Shuangbai Tablets |
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| YANG Wan-hua,LI Juan,CHEN Bing.Study on Quality Standard of Shuangbai Tablets[J].China Pharmacy,2010(27):2549-2551. |
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| Authors: | YANG Wan-hua LI Juan CHEN Bing |
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| Institution: | (Dept.of Pharmacy,Ruijin Hospital of Shanghai Jiaotong University Sch-ool of Medicine,Shanghai 200025,China)HAO Xiao-jing(Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)YAO Ying,SHI Hui-juan(Shanghai Shanglian Pharmaceutical Co.,Ltd.,Shanghai 201703,China) |
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| Abstract: | OBJECTIVE：To establish quality standards of Shuangbai tablet.METHODS：Identification of Astragalus membranaceus,Acanthopanax senticosus and Paeoniae lactiflora was carried out by TLC.The content of paeoniflorin in Shuangbai tablet was determined by HPLC.RESULTS：The TLC spots of A.membranaceus,A.senticosus and P.lactiflora were same to some TLC spots of reference substance.TLC spots were specific.The linear range of paeoniflorin were 3.20-64.00 μg·mL^-1（r=0.999 3） with an average recovery of 99.12%（RSD=1.18%,n=6）.CONCLUSION：Established standard can be used for the quality control of Shuangbai tablets. |
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| Keywords: | Shuangbai tablet TLC HPLC Quality standard |
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