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| 表面活性剂对硫糖铝胶囊药剂学的影响研究 | |
| 引用本文： | 王勤,顾王文,柳晨.表面活性剂对硫糖铝胶囊药剂学的影响研究[J].中国药房,2005,16(15):1138-1140. |
| 作者姓名： | 王勤 顾王文 柳晨 |
| 作者单位： | 1. 上海第二医科大学附属仁济医院药剂科,上海市,200001 2. 中国科学院上海药物研究所,上海市,201203 3. 复旦大学药学院药剂教研室,上海市,200032 |
| 摘 要： | 目的:考察表面活性剂对硫糖铝胶囊的药剂学指标的影响,并筛选出其在处方中的用量。方法:分别加入不同表面活性剂,制备硫糖铝胶囊,并测定成品的崩解度、溶出度和分散性,用威布尔分布模型拟合溶出曲线,比较各种表面活性剂及其不同用量对硫糖铝溶出的影响。结果:十二烷基硫酸钠对硫糖铝的溶出促进作用最大,当其加入量为2%时,胶囊的各项药剂学指标最优。结论:硫糖铝胶囊宜选用2%十二烷基硫酸钠为表面活性剂。 |
| 关 键 词： | 硫糖铝 胶囊 表面活性剂 十二烷基硫酸钠 |
| 文章编号： | 1001-0408（2005）15-1138-03 |
| 收稿时间： | 2004-11-02 |
| 修稿时间： | 2005-01-29 |
Study on the Pharmaceutical Effect of Surfactants on the Sucralfate Capsule |
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| WANG Qin,GU Wangwen,LIU Chen.Study on the Pharmaceutical Effect of Surfactants on the Sucralfate Capsule[J].China Pharmacy,2005,16(15):1138-1140. | |
| Authors: | WANG Qin GU Wangwen LIU Chen |
| Abstract: | OBJECTIVE:To study the effect of surfactants on the pharmaceutical index of sucralfate capsule and to optiˉmize its dosage used in the formula.METHODS:The sucralfate capsule was prepared with different surfactants respectively.The disintegration,dissolution and dispersibility of the preparations were determined and their stripping curves were fitted with Weibull distribution model.Different surfactants and the effects of different dosages of which on the dissolution of suˉcralfates were compared.RESULT:The sodium lauryl sulphate had the biggest promotion effect on the dissolution of sucralˉfate.Optimal indexes of the capsule were achieved when the addition of sodium lauryl sulphate was2%.CONCLUSION:It is advisable to adopt2%sodium lauryl sulphate as the surfactants for the sucralfate capsule. |
| Keywords: | Sucralfate Capsule Surfactants Sodium lauryl sulphate |
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