血尿酸浓度与原发性高血压冠心病病情程度关系

目的　探讨血尿酸浓度与原发性高血压 (EH) ,冠心病 (CHD)病情程度的相关性。方法　采用酶学法 ,用全自动生化分析仪AU 4 0 0测定血尿酸浓度。结果　 10 8例EH患者血尿酸浓度为 (4 2 2 .83± 15 0 .6 6 )μmol/L ,高血尿酸症 (HUA)总发生率为 4 2 .6 %。其中 :Ⅲ级EH患者血尿酸水平较Ⅰ级EH患者尿酸水平显著升高 (P <0 .0 5 ) ,Ⅲ级EH患者较Ⅱ级EH患者血尿酸水平、Ⅱ级EH患者血尿酸水平较Ⅰ级EH患者血尿酸水平显著升高 (P <0 .0 5 ) ,冠心病 (CHD)患者血尿酸浓度为 (4 31.83± 15 1.36 ) μmol/L ,高血尿酸症 (HUA)总发生率为 4 3.1%。冠状动脉 2支或 2支以上病变与高血尿酸检出率成正相关 (P <0 .0 5 )。结论　HUA与EH、CHD的发生率及病情程度关系密切

Study on Relationship of Serum Uric Acid and Degree of Primary Hypertension and Coronary Heart Disease

Objective To analyze the relationshipbetween the serum uric acid (UA) egree of primary hypertension (PH) and coronary heart disease (CHD). Methods The uric acid was detected with auto analyzer of AU400 with enzyme method. Results The uric acid concentration was 422.83±150.66 μmol/L. The incidence f HUA was 42.6%, among them level of UA of degree Ⅳ was higher than that of degree Ⅲ (P<0.05) and decreased with the degree of hypertension. The UA level of CHD was 431.83±151.36 μmol/L with total incidence of 43.1%. The branche of CHD involved was parallel with the level of UA. Conclusion The incidence of hyper UA was related with the degree of primary hypertension and CHD.