| 通脉颗粒长期毒性实验研究 |
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| 引用本文： | 熊玉霞,肖顺汉,李亮,李华. 通脉颗粒长期毒性实验研究[J]. 泸州医学院学报, 2004, 27(5): 387-390 |
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| 作者姓名： | 熊玉霞 肖顺汉 李亮 李华 |
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| 作者单位： | 泸州医学院药学院药理教研室,四川,泸州,646000 |
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| 摘 要： | 目的 :观察通脉颗粒对大鼠的长期毒性作用。方法 :大鼠用通脉颗粒连续灌胃给药 ,观察其一般情况、体重 ,进行血常规、血生化检测和主要脏器的病理组织学检查。结果 :给药期间及停药后大鼠的一般情况无异常 ,无动物死亡 ;体重增加值、血常规、血生化等指标均无显著性差异 (P >0 .0 5 ) ;各脏器的病理组织学检查无异常。结论 :各剂量组通脉颗粒未显示长期毒性作用。
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| 关 键 词： | 通脉颗粒 长期毒性 大鼠 |
| 文章编号： | 1000-2669(2004)5-0387-04 |
| 修稿时间： | 2004-01-20 |
STUDY ON THE CHRONIC TOXICOLOGICAL EFFECT OF TRADITIONAL MEDICINE TONGMAI GRANULE ON WISTER RATS |
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| Xiong Yuxia,et al. STUDY ON THE CHRONIC TOXICOLOGICAL EFFECT OF TRADITIONAL MEDICINE TONGMAI GRANULE ON WISTER RATS[J]. Journal of Luzhou Medical College, 2004, 27(5): 387-390 |
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| Authors: | Xiong Yuxia et al |
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| Affiliation: | Xiong Yuxia,et alDepartment of Pharmacology,Luzhou Medical College |
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| Abstract: | Objective: To observe the chronic toxicological effect of traditional medicine TongMai Granule on rats. Methods: Rats were administrated orally with TongMai Granule for 12 weeks, changes in the general condition and weight of rats were observed in the course of treatment; and changes in the blood-picture and blood-biochemistry and histopathology in leading organs were detected. Results: The general condition of all rats has no marked change and not a rat died; Compared with control group, no significant change in every index of experiment groups was found(P>0.05)and no notable histopathological change was observed. Conclusion: The results suggest that TongMai Granule has no chronic toxicological effect on rats. |
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| Keywords: | TongMai Granule Chronic toxicological effect Rats |
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