Albumin gene encoding free fatty acid and β-amyloid transporter is genetically associated with Alzheimer disease |
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| Authors: | RYO KIMURA md KOUZIN KAMINO md phd MITSUKO YAMAMOTO bs TOMOYUKI KIDA md phd HIROYASU AKATSU md phd TAKESHI UEMA md phd TOSHIKO KOBAYASHI md phd HIDEYUKI HATTORI md phd AIDARALIEVA NURIPA md BEGUM NURUN NESSA md HIROAKI KAZUI md phd YOSHITAKA IKEJIRI md phd TOSHIHISA TANAKA md phd HISASHI TANII md phd TAKASHI KUDO md phd HIROSHI YONEDA md phd HIDEHISA YAMAGATA md phd TETSURO MIKI md phd AND MASATOSHI TAKEDA md phd |
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| Affiliation: | Division of Psychiatry and Behavioral Proteomics, Department of Post-Genomics and Diseases, Osaka University Graduate School of Medicine, Suita,;Choju Medical Institute, Fukushimura Hospital, Toyohashi,;Department of Psychiatry, Osaka General Medical Center, Osaka,;Department of Social Services, Faculty of Human Services, Osaka University of Human Sciences, Settsu,;Department of Psychiatry, National Hospital for Geriatric Medicine, Ohbu,;Department of Neuropsychiatry, Osaka Medical College, Takatsuki,;Department of Medical Genetics,;Department of Geriatric Medicine, School of Medicine, Ehime University, Toon, Japan and;Department of Psychiatry, Mie University, Mie, Japan |
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| Abstract: | Abstract Alzheimer disease (AD), the major cause of dementia in the elderly, is characterized by β-amyloid deposition in senile plaques and hyperphosphorylated tau in neurofibrillary tangles. Since albumin, binding and transporting free fatty acids is also the major transporter of β-amyloid, we examined the association between the albumin ( ALB ) gene and the occurrence of late-onset AD (LOAD). We found that the allele distribution of the intron 4 microsatellite of the ALB gene showed a significant difference ( P < 0.05) between LOAD ( n = 285) and control group ( n = 656). An allele with 11 CA repeat, termed (CA)11 allele, was significantly predominant in the control group ( P < 0.005), and the odds ratio carrying the (CA)11 allele was 0.43 ( P < 0.01, 95% CI = 0.24–0.79). Logistic regression indicated that this effect was independent of age and the ɛ4 dose of the apolipoprotein E gene ( P < 0.01), while the ALB gene was supposed to be related to aging. Our results indicate that the ALB gene is genetically related with the occurrence of LOAD, supporting the link between fatty acid and β-amyloid transport in the development of LOAD. |
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| Keywords: | albumin Alzheimer's disease β-amyloid fatty acids microsatellite |
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