| 拉曼光谱法测定硫普罗宁注射液的含量 |
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| 引用本文： | 张锐,石蓓佳,王玉.拉曼光谱法测定硫普罗宁注射液的含量[J].中国药学杂志,2012,47(3):232-235. |
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| 作者姓名： | 张锐 石蓓佳 王玉 |
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| 作者单位： | 中国药科大学;江西中医学院现代中药制剂教育部重点实验室;江苏省食品药品检验所 |
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| 摘 要： | 目的 建立拉曼光谱法测定硫普罗宁注射液含量的方法。方法 利用拉曼散射原理，在水溶液中，拉曼峰信号的强度与溶质分子的浓度成正比，选取样品溶液拉曼光谱中硫普罗宁的巯基S-H振动(2 580 cm-1)处的强峰作为定量峰，建立拉曼光谱法测定硫普罗宁注射液含量的方法。结果 硫普罗宁在10～100 mg·mL-1内与拉曼峰强度呈良好的线性关系，线性回归方程为Y=166.1ρ-30.92，线性相关系数为0.999 9（n=6），平均回收率为101.98%，RSD为2.09%（n=9）。结论 本方法操作简便、快速，可用于硫普罗宁注射液的含量测定。
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| 关 键 词： | 激光拉曼光谱|硫普罗宁|含量测定
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| 收稿时间： | 2012-03-01; |
Quantitative Determination of Tiopronin Injection by Raman Spectroscopy |
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| ZHANG Rui,SHI Bei-jia,WANG Yu.Quantitative Determination of Tiopronin Injection by Raman Spectroscopy[J].Chinese Pharmaceutical Journal,2012,47(3):232-235. |
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| Authors: | ZHANG Rui SHI Bei-jia WANG Yu |
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| Institution: | 1,3(1.China Pharmaceutical University,Nanjing 210009,China;2.Jiangxi University of Traditional Chinese Medicine,Modern Preparation of Traditional Chinese Medicine,Ministry of Education,Nanchang,330004,China;3.Jiangsu Institute for Food and Drug Control,Nanjing 210008,China) |
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| Abstract: | OBJECTIVE To establish a Raman spectroscopy method for the determination of tiopronin injection.METHODS Based on Raman scattering theory,the light intensity of the laser Raman peak is in proportional to the concentration of tiopronin samples in aqueous solution.A quantitative method for determination of tiopronin injection using Raman spectroscopy was established by selecting the Raman peak of tiopronin sulfhydryl group(S-H2 580 cm-1]) as quantitative peak.RESULTS The calibration curve was linear over the range of 10-100 mg·mL-1(r= 0.999 9,n=6),and the average recovery was 101.98% with RSD of 2.09%(n=9).CONCLUSION The method is convenient and rapid.It is expected to be used in the quality control of tiopronin injection. |
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| Keywords: | Laser Raman spectra tiopronin determination |
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