妊高征患者血清血小板生长因子含量变化的意义

目的:探讨血小板生长因子在妊高征发病中的作用,进一步阐明妊高征发病机制。方法:运用酶联免疫吸附法测定30例妊高征患者(妊高征组,其中轻度10例,中重度20例)、13例正常晚孕妇女(正常晚孕组)血清中血小板生长因子含量。结果:血小板生长因子含量在正常晚孕组为(39.61±18.20)pg/ml,在轻度妊高征组为(49.48±25.40)pg/ml,在中重度妊高征组为(83.54±34.52)pg/ml。正常晚孕组与轻度妊高征组比较,差异无显著性(P>0.05);正常晚孕组与中重度妊高征组比较,差异有极显著性(P<0.001);轻度妊高征与中重度妊高征组比较,差异有显著性(P<0.05)。结论:妊高征患者血清中血小板生长因子含量变化与妊高征发病及病情的严重程度有关。

CHANGES OF SERUM PLATELET-DERIVED GROWTH FACTOR IN PATIENTS WITH PREGNANCY INDUCED HYPERTENSION

Objective:To study the role of platelet-derived growth factor (PDGF) in the etiology of pregnancy-induced hypertension (PIH), go step further to clarify the pathogenesis of PIH.Methods:Levels of serum PDGF were measured by means of enzyme-linked immunosorbent assay. (ELISA). Candidates including normal late-pregnancy group (n=13), mild-PIH group (n=10), moderate-severe PIH group (n=20).Results:The levels of PDGF in normal pregnant group is (39.61±18.20)pg/ml, in moderate-severe PIH group is(83.54 ±34.52)pg/ml, in mild PIH group is (49.48±25.40) pg/ml. PDGF concentration in moderate-severe PIH group is higher than those in mild PIH group(P＜0.05) and normal pregnant group(P＜0.001). There was no significantly statistical difference between normal late-pregnancy group and mild PIH group(P＞0.05).Conclusions:Change of serum levels of PDGF is related to pathogenesis and degree of development in PIH.