The effect of helicobacter pylori eradication on macrophage migration inhibitory factor, c-reactive protein and fetuin-a levels |
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Authors: | Levent Kebapcilar Oktay Bilgir Elif Cetinkaya Murat Akyol Ferda Bilgir Giray Bozkaya |
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Affiliation: | 1Izmir Bozyaka Training and Research Hospital, Department of Internal Medicine – Izmir/Turkiye;2Izmir Bozyaka Training and Research Hospital, Department of Biochemistry – Izmir/Turkiye |
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Abstract: | OBJECTIVES:To determine the effect of Helicobacter pylori (H. pylori) eradication on blood levels of high-sensitivity C-reactive protein (hs-CRP), macrophage migration inhibitory factor and fetuin-A in patients with dyspepsia who are concurrently infected with H. pylori.METHODS:H.pylori infection was diagnosed based on the 14C urea breath test (UBT) and histology. Lansoprazole 30 mg twice daily, amoxicillin 1 g twice daily, and clarithromycin 500 mg twice daily were given to all infected patients for 14 days; 14C UBT was then re-measured. In 30 subjects, migration inhibitory factor, fetuin-A and hs-CRP levels were examined before and after the eradication of H. pylori infection and compared to levels in 30 healthy subjects who tested negative for H. pylori infection.RESULTS:Age and sex distribution were comparable between patients and controls. Migration inhibitory factor and hs-CRP levels were higher, and fetuin-A levels were lower, in H. pylori-infected patients (p<0.05). Following eradication of H. pylori, migration inhibitory factor and hs-CRP levels were significantly decreased, whereas fetuin-A levels were increased. However, eradication of the organism did not change lipid levels (p>0.05).CONCLUSION:These findings suggest that H. pylori eradication reduces the levels of pro-inflammatory cytokines such as migration inhibitory factor and hs-CRP and also results in a significant increase in anti-inflammatory markers such as fetuin-A. |
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Keywords: | Helicobacter pylori Eradication Fetuin-A Macrophage migration inhibitory factor High-sensitivity C-reactive protein |
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