Antiviral effect of a selective COX-2 inhibitor on H5N1 infection in vitro |
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| Authors: | Lee Suki M Y Gai W W Cheung Timothy K W Peiris J S M |
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| Affiliation: | a Department of Microbiology, The University of Hong Kong, Hong Kong, China
b University of Hong Kong - Pasteur Research Centre, The University of Hong Kong, Hong Kong, China |
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| Abstract: | A selective cyclooxygenase-2 (COX-2) inhibitor has been previously shown to suppress the hyper-induced pro-inflammatory responses in H5N1 infected primary human cells. Here, we demonstrate that COX-2 inhibitors suppress H5N1 virus replication in human macrophages suggesting that H5N1 virus replication (more so than seasonal H1N1 virus) is dependent on activation of COX-2 dependent signaling pathways in host cells. COX-2 and its downstream signaling pathways deserve detailed investigation as a novel therapeutic target for treatment of H5N1 disease. |
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| Keywords: | Influenza H5N1 Antiviral Selective COX-2 inhibitor |
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