50例多索茶碱治疗慢性阻塞性肺疾病急性加重期的临床疗效

目的比较多索茶碱与氨茶碱治疗急性加重期慢性阻塞性肺疾病（AECOPD）的临床疗效。方法将50例慢性阻塞性肺疾病急性加重期的患者随机分为研究组和对照组，均进行常规治疗，研究组加用多索茶碱200nag，对照组加用氨茶碱250mg，1次／d，治疗周期均为7～12d，治疗结束后比较治疗效果。结果治疗后，研究组患者临床症状体征改善情况显著优于对照组（P〈0．05），两组患者肺功能指标改善情况差异有统计学意义（P〈0．05）。结论多索茶碱在控制慢性阻塞性肺疾病急性加重期的病情、改善患者肺功能方面优于氨茶碱，值得推广应用。

Clinical efficacy of doxofylline and aminophylline in treating acute exacerbation chronic obstructive pni. monary disease

Objective To compare the clinical efficacy of doxofylline and aminophylline in treating a- cute exacerbation chronic obstructive pulmonary disease （AECOPD）. Methods 50 patients of AECOPD were randomly divided into study group and control group. Besides from conventional therapy. The patients of the stud- y group were treated with doxofylline 200 rag, while the control group were treated with aminophylline 250 mg once a day, the clinical efficacy were compared after 7 days. Results After treatment, the clinical symptoms of the study group improved significantly better than the control group （ P 〈 0. 05 ）, there was a significant differ- ence on lung function in two groups （ P 〈 0. 05 ）. Conduslon The clinical efficacy to improve lung function of doxofyUine is superior to aminophyffine in treating AECOPD, should be widely applied.