| 2型糖尿病合并代谢综合征患者颈动脉内膜——中层厚度与ICAM-1及胰岛素抵抗的关系 |
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| 引用本文： | 王怡,王锐,孙立军,张芳,张美喜. 2型糖尿病合并代谢综合征患者颈动脉内膜——中层厚度与ICAM-1及胰岛素抵抗的关系[J]. 山东医药, 2010, 50(9): 23-25 |
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| 作者姓名： | 王怡 王锐 孙立军 张芳 张美喜 |
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| 作者单位： | 秦皇岛市第一医院,河北秦皇岛,066000 |
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| 基金项目： | 秦皇岛市科学技术研究与发展计划 |
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| 摘 要： | 目的探讨2型糖尿病（T2DM）合并代谢综合征（MS）患者颈动脉内膜-中层厚度（CIMT）与细胞间黏附分子-1（ICAM-1）及胰岛素抵抗的关系。方法将108例T2DM患者按有无MS分为两组，分别进行血压、血糖、血脂、空腹血清胰岛素及ICAM-1检测，并行B超检查测量CIMT。结果与不合并MS组比较，T2DM合并MS组CIMT增厚（P〈0．05），血清ICAM-1、胰岛素、BMI、血压、TG、胰岛素抵抗指数（HOMA-IR）均明显升高（P均〈0．05），MS组分数越多，ICAM-1水平越高，CIMT越厚。多元逐步回归分析显示，CIMT与ICAM-1、年龄、HOMA—IR呈正相关。结论T2DM合并MS患者较不合并MS患者血清ICAM-1升高，CIMT增厚。
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| 关 键 词： | 细胞间黏附分子 颈动脉内膜-中层厚度 糖尿病，2型 代谢综合征 |
Relationship of carotid intima-media thickness with serum intercellular adhesion molecule-1 and insulin resistance in type 2 diabetes mellitus with metabolic syndrome |
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| WANG Yi,WANG Rui,SUN Li-jun,ZHANG Fang,ZHANG Mei-xi. Relationship of carotid intima-media thickness with serum intercellular adhesion molecule-1 and insulin resistance in type 2 diabetes mellitus with metabolic syndrome[J]. Shandong Medical Journal, 2010, 50(9): 23-25 |
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| Authors: | WANG Yi WANG Rui SUN Li-jun ZHANG Fang ZHANG Mei-xi |
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| Affiliation: | WANG Yi,WANG Rui,SUN Li-jun,ZHANG Fang,ZHANG Mei-xi (First Hospital of Qinhuangdao,Qinhuangdao 066000,P.R.China) |
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| Abstract: | Objective To investigate the relationship of carotid intima-media thickness(IMT) with insulin resistance and serum intercellular adhesion molecule-1(ICAM-1) level in type 2 diabetes mellitus(T2DM) with metabolic syndrome.Methods One hundred and eight patients with T2DM were divided into two groups by metabolic syndrome(MS).Blood samples were collected and fasting plasma glucose,serum lipids,true insulin and sICAM-1 were assayed.Results Compared with T2DM without MS,CIMT was thicker(P<0.05),ICAM-1 level,insu... |
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| Keywords: | intercellular adhesion molecule-1 carotid intima-media thickness diabetes mellitus type 2 metabolic syndrome |
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