心房利钠肽与妊娠期高血压疾病相关性研究

目的探讨心房利钠肽(ANP)与妊娠期高血压(PIH)的相关性及其临床意义。方法选取2009年1月～2011年12月期间诊治的妊娠期高血压患者共100例作为观察对象(PIH组),其中妊娠期高血压62例(A组),轻度子痫前期28例(B组),重度子痫前期10例(C组)。随机选取同期孕周在30周-37周之间的正常妊娠孕妇100例作为对照组。检测ANP、BNP,观察终止妊娠周数及新生儿出生体重。结果 PIH组ANP、BNP测定平均值为(197.12±20.11)pg/ml、(17.63±5.34)pg/ml明显高于对照组测定值为(68.81±12.87)pg/ml、(8.57±2.66)pg/ml,差异有统计学意义(P﹤0.05);PIH组、A组、B组、C组ANP分别为(197.12±20.11)pg/ml、(184.76±20.24)pg/ml、(198.82±18.89)pg/ml、(220.38±20.22)pg/ml,明显高于对照组测定值为(68.81±12.87)pg/ml,与对照组差异有统计学意义(P﹤0.05);PIH组、B组、C组BNP为(17.63±5.34)pg/ml、(18.87±4.32)pg/ml、(47.85±11.73)pg/ml、高于对照组(8.57±2.66)pg/ml,与对照组差异有统计学意义(P﹤0.05);C组ANP、BNP与A组、B组差异有统计学意义(P﹤0.05),B组与A组差异有统计学意义(P﹤0.05);PIH组、B组、C组终止妊娠周数、新生儿体重低于与对照组,差异有统计学意义(P﹤0.05),C组与A组、B组之间差异有统计学意义(P﹤0.05),终止妊娠周数在B组与A组间差异有统计学意义(P﹤0.05)。结论妊娠期高血压疾病患者血浆ANP、BNP均明显高于正常孕妇,并且与妊娠期高血压疾病严重程度存在正相关。

Correlation between atrial natriuretic peptide and pregnancy-induced hypertension disease

OBJECTIVE To explore the correlation between atrial natriuretic peptide(ANP)and pregnancy-induced hypertension(PIH)and clinical value of atrial natriuretic peptide.METHODS Selected 100 cases of pregnancy-induced hypertension patients,from January 2009 to December 2011(PIH group),62 cases of which were pregnancy-induced hypertension(A group),28 cases of which were mild preeclampsia(B group),10 cases of which are severe preeclampsia(C group).Randomly selected 100 cases of normal pregnancy as control group at the same time,whose gestational week was between 30 weeks and 37 weeks.ANP and BNP were tested.The termination of pregnancy week number and neonatal birth weight were observed.RESULTS In PIH group,average values of ANP,BNP were(197.12 ± 20.11)pg/ml,(17.63 ± 5.34)pg/ml,which were apparently higher than the control group,whose were(68.81 ± 12.87)pg/ml,(8.57 ± 2.66)pg/ml.It was significantly different(P﹤0.05).The ANP of PIH group,A group,B group,C group were(197.12 ± 20.11)pg/ml,(184.76 ± 20.24)pg/ml,(198.82 ± 18.89)pg/ml,(220.38 ± 20.22)pg/ml respectively,which was apparently higher than the control group,whose was(68.81 ± 12.87)pg/ml.It was significantly different from control group(P﹤0.05).BNP of PIH group,B group,C group were(17.63 ± 5.34)pg/ml,(18.87 ± 4.32)pg/ml,(47.85 ± 11.73)pg/ml,which was higher than the control group,whose was(8.57 ± 2.66)pg/ml.It was significantly different from control group(P﹤0.05).ANP,BNP of C group and A group,B group were significantly different(P﹤0.05).A group and B group were also significantly different(P﹤0.05).The termination of pregnancy week number,neonatal birth weight of PIH group,B group,C group was lower than control group.It was significantly different(P﹤0.05).C group was significantly different from A group,B group(P﹤0.05).The termination of pregnancy week number was significantly different in A group and B group(P﹤0.05).CONCLUSION ANP,BNP of pregnancy-induced hypertension patients are apparently higher than normal pregnancy,and it has a positive correlation with the severity of pregnancy-induced hypertension disease.