石河子市儿童流行性腮腺炎疫苗免疫效果评价

目的评价儿童接种流行性腮腺炎疫苗的免疫效果。方法采用组群抽样的方法,抽取在12～18个月接种过流腮疫苗的1～8岁儿童共769名,用酶联免疫法原(ELLSA)定性测定流腮IgG抗体。结果 1岁～组的抗体阳性率最低(31.15%),2岁～组抗体阳性率最高(67.19%),2岁～组以后随年龄的增长抗体水平呈下降趋势,并进行趋势卡方检验差异有统计学意义(χ2=477.22,P﹤0.005),男女间腮腺炎抗体阳性率差异无统计学意义(χ2=0.077,P﹥0.05),常住儿童抗体阳性率高于暂住人口(χ2=3.92,P﹤0.05)。结论石河子市儿童接种1剂次腮腺炎疫苗后,腮腺炎抗体水平处于较低水平,建议采取2剂次的接种方案。

Evaluation on the immune effect of mumps vaccine among children in Shihezi

OBJECTIVE To investigate the immune effect of mumps vaccine. METHODS The serum samples were collected according to the method of probability proportional to size (PPS) from 769 children aged 1 to 8 years who were given mumps vaccine during 12 and 18 months. The mumps IgG antibody was detected by ELISA test. RESULTS The antibody positive rate was the lowest ( 31.15% ) in babies less than 2 years, while the antibody positive rate was the highest among children (67.19%) less than 3 years. Children older than 2 years old, the antibody positive rate was significantly decreased with age (χ2 = 477.22, P﹤0.005), and the positive rate of mumps IgG antibody was higher in the permanent resident children than that in the temporary resident children (χ2 = 3.92, P﹤0.05). CONCLUSION The mumps IgG antibody rate was lower in children in Shihezi after once vaccination. Therefore, the two times vaccination method may be more effective.