瘦素受体及雌激素受体在肺癌中的表达

目的 研究瘦素受体及雌激素受体在肺癌及肺正常组织中的表达差别.方法 对肺癌组织及肺正常组织各30例标本行免疫组化染色法,检测瘦素受体和雌激素受体的表达,并比较这两种受体在肺癌及肺正常组织中表达的差异以及在不同类型肺癌中表达的差异,探讨其与肺癌之间的关系.结果 30例肺正常组织标本中瘦素受体及雌激素受体的阳性表达率分别为26.67％ (8/30)及0％(0/30).30例肺癌组织标本中瘦素受体及雌激素受体的阳性表达率分别为73.33％ (22/30)及63.33％ (19/30),均明显高于正常组(P＜0.05)；瘦素受体及雌激素受体在肺正常标本中的阳性表达率差异有统计学意义(P＜0.05),而在肺癌组织标本中差异无统计学意义(P＞0.05).肺癌标本中瘦素受体及雌激素受体的表达在性别和肺癌类型差异无统计学意义(P＞0.05).结论 瘦素受体及雌激素受体在肺癌组织中均呈现高表达,与肺癌的发生可能存在一定相关性.

Expression of Leptin receptor and Estrogen2 receptor in lung carcinoma

OBJECTIVE To study the expression of Leptin receptor and Estrogenre2 receptor in lung carcinoma.METHODS The expressions of Leptin receptor(OB-R)and Estrogenre2 receptor(ER)were detected in 30 cases of pulmonary malignant tumor tissues and 30 cases of the normal pulmonary tissues by immunohistochemistry.The different expressions between pulmonary malignant tumor tissues and the normal pulmonary tissues among different pulmonary type swere compared.The correlation between the i expression and parameters was also analyzed.RESULTS In 30 normal pulmonary tissues,the expression rate of OB-R and ER was 26.67%(8/30)and 0%(0/30),respectively.In 30 pulmonary benign lesion tissues,the expression rate of OB-R and ER was 73.33%(22/30)and 63.33%(19/30),respectively.The differences were considered to significant(P﹤0.05).In normal pulmonarytissues,these differences between the expression rates of OB-R and ER had statistical values(P﹤0.05),however,in the pulmonary malignant tumor tissues,they had no statistical values(P﹥0.05).These differences had no statistical values among the patients’ sex,histology typing(P﹥0.05).CONCLUSION OB-R and ER are expressed highly in lung carcinoma.They may participate in the malignant transformation of lung.