张家港市人群乙型病毒性肝炎血清流行病学调查

目的 了解张家港市人群乙型病毒性肝炎流行状况,为乙肝防制提供参考依据.方法在张家港市随机整群抽取20个村(社区)的常住人口共50 886人,开展问卷调查,采集静脉血,进行乙肝血清学实验室检测.结果 全人群HBsAg阳性率为5.15％,抗-HBs阳性率为52.69％.各地区间HBsAg阳性率和抗-HBs阳性率差异无统计学意义.男女HBsAg阳性率分别为5.72％和4.68％,抗-HBs阳性率分别为51.56％和53.62％,两者间差异均有统计学意义.各年龄组间HBsAg阳性率和抗-HBs阳性率差异均有统计学意义,0～14岁人群HBsAg阳性率较低,25 ～59岁人群HBsAg阳性率较高.有明确免疫史人群的HBsAg阳性率明显低于未免疫或免疫不详人群,抗-HBs阳性率明显高于未免疫或免疫不详人群.结论 接种乙肝疫苗是控制人群HBV感染的有效措施,应进一步加强对25～59岁组青壮年人群的乙肝干预措施.

Analysis of positive rate of HBsAg in population of Zhangjiagang city

OBJECTIVE To analyze the prevalence of virus B hepatitis in population of Zhangjiagang city and provide scientific evidences for effective prevention and control of hepatitis B.METHODS Questionnaire survey was conducted among 50 886 resident people from 20 villages/communities selected by random clustering sampling.Venous blood was sampled and tested using enzyme-linked immunosorbent assay(ELISA).RESULTS The positive rate of HBsAg and anti-HBsAg was 5.15% and 52.69%.No significant differences were found among the positive rates of HBsAg and anti-HBsAg in different regions.The positive rate of HBsAg of the male and female was 5.27% and 4.68%,and anti-HBsAg 51.56% and 53.62%,respectively,and significant differences were both found between different gender groups.Significant differences were also found in the positive rates of HbsAg and anti-HBsAg among the different age groups,and the positive rates were lower in the age groups of 0-14 years and higher in the age groups of 25-59 years.The positive rate of HBsAg in immunized group was obviously lower than unimmunized group,while the positive rate of anti-HBsAg was opposite.CONCLUSION Hepatitis B vaccine is the effective measure to control HBV infection and the intervention should be reinforced in age group of 25-59 years.