C-反应蛋白检测在新生儿败血症中的应用价值研究

目的 探讨败血症新生儿C-反应蛋白(CRP)的变化以及CRP在新生儿败血症中的诊断价值.方法 对某院26例新生儿败血症患儿(败血症组)及30例正常健康新生儿(对照组)采取散射比浊法测定血清CRP水平,并且同时检测WBC计数及血培养做为对照.结果 败血症组患儿血清CRP (56.13±32.87) mg/L、WBC (24.37±7.84) ×109/L,明显高于对照组新生儿CRP (5.38±2.11) mg/L、WBC (7.78±1.32) ×109/L,两组之间差异有统计学意义(P＜0.05)；败血症组血培养阳性20例,阳性患儿CRP阳性率90.00％,WBC阳性率70.00％,CRP与血培养之间差异无统计学意义(x2=0.53,P＞0.05),WBC与血培养之间差异有统计学意义(x2=4.90,P＜ 0.05).结论 CRP检测有助于协助新生儿败血症的诊断,可为早期诊断提供诊断依据.

Study on the value of C-reactive protein detection in neonatal sepsis

OBJECTIVE To study the sepsis neonatal C-reactive protein(CRP)changes,as well as the diagnostic value of CRP in neonatal sepsis.METHODS Took 26 cases of neonatal sepsis(sepsis group)and 30 normal healthy newborns(control group)to detect serum CRP levels with nephelometry and simultaneously detected WBC count and conducted blood culture as controls.RESULTS In children with sepsis group,the serum CRP(56.13 ± 32.87)mg/L,the WBC(24.37 ± 7.84)×109/L,was significantly higher than newborns of CRP(5.38 ± 2.11)mg/L,WBC(7.78 ± 1.32)×109/L,and there was a significant difference(P﹤0.05);sepsis group,20 cases of positive blood culture,positive children with CRP-positive rate of 90.00%,the WBC-positive rate of 70.00%,no significant difference between CRP and blood culture(χ2 = 0.53,P﹥0.05)between the WBC and blood culture,there was a significant difference(χ2 = 4.90,P﹤0.05).CONCLUSION CRP testing can help to assist in the diagnosis of neonatal sepsis,and to provide diagnostic evidence for the early diagnosis.