局部晚期宫颈癌同步放化疗疗效观察

目的观察局部晚期宫颈癌患者采取同步放化疗治疗的临床效果及不良反应。方法选取170例局部晚期宫颈癌患者,并随机分为两组,85例采取同步放化疗为观察组,85例采取单纯放射治疗为对照组,分别对两组患者近期疗效、远期疗效及不良反应发生情况进行统计分析。结果观察组治疗总有效率为60.00%,对照组治疗总有效率为41.18%,两组差异有统计学意义(P﹤0.05)。随访所有患者1～3年期间,观察组复发率明显低于对照组,3年生存率明显高于对照组,差异有统计学意义(P﹤0.05)。观察组35(41.17%)例早期发生消化道症状,对照组15(17.6%)例早期发生消化道症状,差异有统计学意义(P﹤0.05)。观察组早期结直肠反应、膀胱反应发生率分别为17.6%(15/85)和15.29%(13/85),对照组分别为15.29%(13/85)和12.94%(11/85),观察组10.59%(9/85)发生放射性直肠炎,对照组7.06%(6/85)发生放射性直肠炎,两组比较差异均无统计学意义。结论局部晚期宫颈癌患者采用同步放化疗治疗,可提高肿瘤局部控制率,提高短期生存率,而且化疗引起的不良反应患者能耐受,不影响放疗进程,值得临床推广使用。

Locally adanced cervical cancer chemoradiation curative effects

OBJECTIVE To observe the locally advanced cervical cancer patients to take the chemoradiation of treating the clinical effect,and the adverse reaction.METHODS 170 cases with locally advanced cervical cancer were selected,and randomly divided into two groups.85 patients took the chemoradiation as observation group and 85 patients took simple radiotherapy as control group.the long-term outcome short-term curative effect and adverse reaction of the two groups of patients were analyzed.RESULTS The total effective rate of the observation group therapy was 60.00%,and the total effective rate of the control group was 41.18%.There was significant difference between the two groups(P﹤0.05).During the 1-3 following up period,the recurrence rate of observation group the was significantly lower than that of the control group,3 years survival rate of observation group was significantly higher than those in the control group,and there was significant difference between the two groups(P﹤0.05).35(41.17%)patients in the observation group showed early gastrointestinal tract symptoms,and 15 cases(17.6%)in the control group occurred early gastrointestinal symptoms.There was significant difference between the two groups(P﹤0.05).The early colorectal reaction and bladder response rates in the observation group was 17.6%(15/85)and 15.29%(13/85),respectively,and were 15.29%(13/85)and 12.94%(11/85)in the control group.10.59% of the observation group(9/85)showed radiation proctopathy,7.06% of the control group occurred radiation proctopathy,and there was significant difference between the two groups.CONCLUSION Patients with the locally advanced cervical cancer received the chemoradiation treatment,which can improve tumor local control and improve short-term survival rate.Patients could tolerate the adverse reactions caused by chemotherapy,and the radiation process was not affected.These treatment are worthy of wide spread in clinic.