奥曲肽联合奥美拉唑治疗肝硬化食管胃底静脉曲张破裂出血疗效观察

目的观察联合应用奥曲肽和奥美拉唑治疗肝硬化并发食管胃底静脉曲张破裂出血的疗效。方法选取2004年1月～2011年7月某院收治的242例肝硬化并发食管胃底静脉曲张破裂出血患者,按照入院顺序随机分为观察组(121例)和对照组(121例),观察组患者给予联合应用奥曲肽和奥美拉唑治疗;对照组患者单用奥曲肽治疗。比较两组患者治疗效果和药物不良反应等情况。结果①观察组患者治疗总有效率为90.08%,明显高于对照组的77.69%;观察组患者治疗后再出血率为0.83%,低于对照组4.96%,两组比较差异均有统计学意义(P﹤0.05)。②观察组患者治疗平均止血时间为(27.8±2.4)h,短于对照组(46.4±3.1)h;观察组患者治疗过程中平均输血量为(267.1±43.7)ml,小于对照组的(538.8±87.3)ml,两组比较差异均有统计学意义(P﹤0.05)。③观察组患者治疗期间发生恶心呕吐18例,对照组治疗期间发生恶心呕吐8例,未经过特殊处理后自行缓解。结论联合应用奥曲肽和奥美拉唑治疗肝硬化并发食管胃底静脉曲张破裂出血可提高治疗有效,降低再出血率,缩短止血时间,而且无明显的不良反应,值得推广应用。

The curative effects of octretide joint prilosec in treatment of liver cirrhosis supervene varicosity burst bleeds in the bottom of the stomach and esophagus

OBJECTIVE To observe the curative effects of octretide joint prilosec treatment for liver cirrhosis supervene varicosity burst bleeds in the bottom of the stomach and esophagus.METHODS From January 2004 to July 2011,242 cases of patients with liver cirrhosis supervene varicosity burst bleeds in the bottom of the stomach and esophagus were randomly divided into observation group(121 patients)and the control group(121 patients)according to the order of hospital.The observation group patients received octretide joint prilosec treatment;The control group patients received octretide treatment.We compared the treatment effect and adverse drug reactions of two groups.RESULTS ① The total effective rate of the observation group(90.08%)was significantly higher than those in the control group(77.69%),The bleed again rate of the observation group after treatment(0.83%)was significantly lower than those of the control group(4.96%).There was statistically significant between the two groups(P﹤0.05).② The average time of stop bleeding in the observation group was 27.8 ± 2.4h,which was shorter than the control group(46.4 ± 3.1h);The average blood transfusions of the observation group(267.1 ± 43.7ml)was less than those of the control group(538.8 ± 87.3 ml),there was significant difference between the two groups(P﹤0.05).③ There were 18 cases of patients with nausea and vomiting during treatment in the observation groups,and there were 8 cases of patients in the control group.All patients eased without special treatment.CONCLUSION Octretide joint prilosec treatment for liver cirrhosis supervene varicosity burst bleeds in the bottom of the stomach and esophagus can improve the treatment efficiency,reduce bleed again rate,shorten the time of stop bleeding,and no obvious adverse reactions,which is worthy to be popularized.