多囊卵巢综合征患者内脂素水平变化及分析

目的 探讨内脂素水平变化与多囊卵巢综合征之间的相互关系.方法 选取2010年1月～2011年12月期间在某院检查确诊的128例多囊卵巢综合征患者(PCOS组),其中肥胖组52例及非肥胖组76例,随机选取门诊同期体检妇女120例作为对照组,观察各组体重指数(BMI)、腰臀比(WER)、血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、孕酮(P)、睾酮(T)、泌乳素(PRL)、内脂素、空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)变化情况.结果 PCOS组BMI、WER、LH、T、FINS、HOMA-IR水平高于对照组,PCOS组内脂素水平(32.27±16.62) ng/ml,对照组(18.83±12.21) ng/ml,两组之间比较差异有统计学意义(P＜0.05)；肥胖组患者BMI、FINS、HOMA-IR水平明显高于非肥胖组患者,肥胖组内脂素水平(34.86±17.14) ng/ml,非肥胖组(27.76±12.27)ng/ml,两组之间比较差异有统计学意义(P＜0.05).结论 多囊卵巢综合征患者血浆内脂素水平较正常人群明显升高,并且在肥胖患者中升高更为明显.

Changes and analysis of visfatin level in polycystic ovary syndrome patients

OBJECTIVE To explore the relationship between visfatin level changes and polycystic ovary syndrome.METHODS Selected 128 patients confirmed and diagnosed polycystic ovary syndrome in our hospital,from January 2010 to December 2011(PCOS group),in obesity group 52 cases,and non-obese group 76 cases.Randomly selected 120 female outpatients during the same period as control group.The changes of body mass index(BMI),waist hip ratio(WHR),serum follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),progesterone(P),testosterone(T),prolactin(PRL),visfatin,fasting blood glucose(FPG),fasting insulin(FINS),insulin resistance index(HOMA-IR)were observed.RESULTS BMI,WHR,LH,T,FINS,HOMA-IR level of PCOS group were higher than control group.Visfatin level of PCOS group was(32.27 ± 16.62)ng/ml,and(18.83 ± 12.21)ng/ml in control group.There were significant differences between the two groups(P﹤0.05).BMI,FINS,HOMA-IR levels of obesity group were significantly higher than non-obese group.Visfatin level of obesity group was(34.86 ± 17.14)ng/ml,and(27.76 ± 12.27)ng/ml in non-obese group.There were significant differences between the two groups(P﹤0.05).CONCLUSION Visfatin level of polycystic ovary syndrome patients is significantly higher than normal population.And the rise among obesity patients is more obvious.