血清胱抑素C在肾脏疾病中的诊断价值

目的 评价血清胱抑素c (cystatinC,CysC)在肾脏疾病的诊断价值.方法 选取CysC结果阳性者(以＞1.03mg/L为阳性标准),计算出CysC阳性患者中SCr(以＞115 μmol/L为阳性标准)、Urea(以＞8.2 mmol/L为阳性标准)、β-MG(以＞3.0 mg/L为阳性标准)、UA(以420 μmol/L为阳性标准)的阳性率.将CysC检测结果分为CysC正常组(≤1.02 mg/L)、轻度增高组(1.03～1.40 mg/L)、中度增高组(1.41～2.00 mg/L)和高度增高组(＞2 mg/L),计算各组中所有项指标的均值.结果 CysC的阳性检出率最高17.00％,SCr为4.00％、Urea为4.30％、β-MG为10.02％、UA为5.00％.CysC、β-MG水平CysC正常组,轻、中、高度增高组组间两两相比,差异有统计学意义(P＜ 0.05); SCr、Urea、UA水平CysC正常组、轻增高组组间中相比差异无统计学意义(P＞0.05),CysC正常组、轻增高组与中度、高度增高组相比差异有统计学意义(P＜0.05),中度、高度增高组相比差异亦有统计学意义(P＜0.05).结论 CysC是肾损害的敏感指标,可作用评价肾脏疾病指标.

Diagnostic value of serum cystatin c in kidney disease

OBJECTIVE To study the value of serum cystatin c(Cystatin C,Cys C)in renal disease diagnosis.METHODS CysC positive patients were selected for study(﹥1.03 mg/L for the positive standard).Positive rates of SCr(﹥115μmol/L as a positive standard),Urea(﹥8.2mmol/L as a positive standard),beta-MG(﹥3.0 mg/L forthe positive standard),UA(420μmol/L as a positive standard)were calculated and analyzed.The results of CysC test were divided into the CysC normal group(≤ 1.02 mg/L),slightly increased group(1.03-1.40 mg/L),moderately increased group(1.41 to 2.00 mg/L)and highly increased group(﹥2 mg/L),and the means of all indicators were calculated in each group.RESULTS Cystatin positive rate reached up to 17.00%,SCr 4.00%,Urea 4.30%,beta-MG 10.02% and UA 5.00%.Cystatin C and beta-MG level of the CysC normal group,slightly increased group,moderately increased group and highly increased group had significant difference with each other(P﹤0.05);SCr,Urea and UA levels of the CysC normal group and the slightly increased group had no significant difference(P﹥0.05),but they were statistically different with the moderately increased group and the highly increased group(P﹤0.05).There was significant difference between the moderately increased group and the highly increased group(P﹤0.05).CONCLUSION Cystatin C is a sensitive indicator of kidney damage which can be used as indicators of kidney disease.