辛伐他汀对维持血液透析患者氧化应激状态的影响

目的 探讨辛伐他汀对维持性血液透析患者氧化应激的影响.方法 选择维持性血液透析的尿毒症患者50例,分为治疗组(n=26)和对照组(n=24),对照组给予常规治疗,治疗组在常规治疗基础上,每晚口服辛伐他汀20 mg,在治疗前、治疗1个月时观察对患者血清丙二(malondialdehyde,MDA)及超氧化物歧化酶(superoxide dismutase,SOD)的影响及血压、血脂.结果 与对照组相比,治疗组患者辛伐他汀治疗1个月后,患者血清SOD水平上升,而MDA水平明显下降,且与治疗前相比差异有统计学意义(P＜0.05);对照组治疗前、后患者血清SOD及MDA水平差异无统计学意义(P＞0.05).结论 辛伐他汀可明显抑制维持性血液透析患者的氧化应激状态.

Effects of oxidative stress in hemodialysis patients with simvastatin state

OBJECTIVE To study the effect of simvastatin on oxidative stress of patients during maintenance hemodialysis(MHD).METHODS 50 patients with chronic renal failure during MHD were randomly divided into treatment group(n = 26)and control group(n = 24).Both groups were administered routine therapy for one month.The treated patients were given additionally simvastatin 20mg.RESULTS The serum levels of SOD and MDA as well as the lipid profile inpatients were observed before and after one month treatment.The results showed that the serum levels of SOD in treatment of patients were significantly high compared with control group.Similarly,patients after one month consecutive simvastalin treatment were significantly high.Whereas the serum level of MDA was significantly low,and it was lower than that before treatment(P﹤0.05).There was no significant difference on the serum levels of SOD and MDA before and after treatment(P﹥0.05).CONCLUSION The simvastatin could significantly inhibit oxidative stress in patients during MHD.