辽宁地区汉族人群多巴胺D2受体基因启动子区-241A/G的多态性研究

目的探讨辽宁地区汉族人群多巴胺D2受体(dopamine D2 receptor,DRD2)基因启动子区-241A/G多态性位点的基因型及等位基因的频率分布。方法用等位基因特异性扩增技术对101名辽宁地区汉族人的DRD2基因启动子区-241A/G多态性进行了检测,并与其他人群做比较。结果 (1)DRD2基因启动子区-241A/G的等位基因频率分别为49%和51%,均符合Hardy-Weinberg平衡定律。(2)中国人群与其他人群基因多态性分布频率对照研究发现,DRD2基因启动子区-241A/G多态性分布存在显著性差异。结论 DRD2基因启动子区-241A/G多态性分布具有种族差异。

Study on-241A/G polymorphisms in the promoters of Dopamine D2 receptor in Chinese Han population in Liaoning

OBJECTIVE To determine the distribution of -241A /G polymorphism in the promoter of dopamine D2 receptor (DRD2) gene in Chinese Han population Liaoning. METHODS A total of 101 healthy Liaoning Hans were studied by the use of allele specific amplification (ASA) techniques. Current results were compared with the data on other ethnic groups. RE- SULTS (1) Within the 101 individuals tested, the frequencies of -241A /G polymorphism in the promoter of the DRD2 gene were found to be 49% and 51%, respectively, which met Hardy-Weinberg equilibrium. (2) There was significant difference in allele distributions of -241A / G polymorphism in the promoter DRD2 between the Liaoning Han population and other ethnic populations. CONCLUSION The distributions of -241A / G polymorphism in the promoter DRD2 gene exhibit ethnic heterogeneity.