FBT预处理方案异基因外周血造血干细胞移植治疗难治／复发急性非淋巴细胞白血病

目的探讨以氟达拉滨＋白舒非＋噻替哌作为预处理方案（FBT预处理方案），进行异基因外周血造血干细胞移植治疗难治／复发急性非淋巴细胞白血病的疗效及可行性。方法以FBT方案作为预处理方案，以环孢素A＋骁悉预防移植物抗宿主病（GVHD），对7例难治／复发急性非淋巴细胞白血病患者进行HLA全相合异基因外周血造血干细胞移植。结果中位随访时间31个月，2例复发，5例患者无病存活。结论FBT预处理方案复发率低，毒副作用轻，相关并发症少，患者耐受性好，对于难治／复发急性非淋巴细胞白血病患者而言，是一种值得进一步探讨的临床治疗方案。

Allogeneic hematopoietic stem cell transplantation using Flu/ivBu/TT conditioning regimen for refractory or relapsed acute non-lymphocytic leukemia

Objective To evaluate the efficacy and feasibility of Flu/ivBu/Tl" conditioning regimen for the treatment of refractory or relapsed acute non-lymphocytic leukemia in patients receiving allogeneic hematopoietie stem cell transplantation. Methods Seven patients with refractory or relapsed acute non-lymphocytic leukemia received HLA identical peripheral blood hematopoietie stem cell transplantation (PBSCT) following Flu/ivBu/TY conditioning regimen, which consisted of fludarbine, busulfex and thiotepa. All patients received cyclos-porin A (CsA) and mycophenolet mofetil (MMF) for prophylaxis of graft - versus - host disease (GVHD). Results The Flu/IVBu/TT regimen was tolerated very well, without severe regimen related toxicity. In the 31-month median follow-up duration, 5 of 7 patients were a-live in disease-free situation. Conclusion The Flu/ivBu/TT conditioning regimen reduced transplantation-related toxicities and offered high long-term disease-free survival, and was tolerated very well. Allogeneie hematopoietie stem cell transplantation using Flu/ivBu/TT condition-ing regimen is a safe and effective option for the patients with refractory/relapsed acute non-lymphocytic leukemia.