| 金樱子醇提物对血清病型肾炎大鼠的药理作用 |
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| 引用本文： | 陈敬民,李友娣.金樱子醇提物对血清病型肾炎大鼠的药理作用[J].时珍国医国药,2006,17(8):1404-1405. |
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| 作者姓名： | 陈敬民 李友娣 |
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| 作者单位： | 广西中医药研究所,广西,南宁,530022 |
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| 基金项目： | 广西壮族自治区科学技术厅青年基金资助项目（桂科青No.0339030）. |
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| 摘 要： | 目的研究金樱子醇提物对血清病型肾炎大鼠的药理作用。方法经大鼠尾静脉注射小牛血清诱发血清病型肾炎,对血清病型肾炎大鼠灌胃给予金樱子醇提物4周,观察金樱子醇提物对血清病型肾炎大鼠的尿肌酐、尿蛋白及血清总蛋白、肌酐和尿素氮的作用。结果金樱子醇提物显著降低血清病型肾炎模型大鼠尿蛋白、血清肌酐和尿素氮水平,升高血清总蛋白含量,减轻肾组织的病理变化。结论金樱子醇提物能减轻血清病型肾炎大鼠模型肾小球病变并改善肾功能。
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| 关 键 词： | 金樱子 血清病型肾炎 药理作用 |
| 文章编号： | 1008-0805（2006）08-1404-02 |
| 收稿时间： | 2005-10-25 |
| 修稿时间： | 2006-03-16 |
Effect of Jinyingzi on the Acute Experimantal Serum Sickness Nephritis in Rats |
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| CHEN Jing-min,LI You-di.Effect of Jinyingzi on the Acute Experimantal Serum Sickness Nephritis in Rats[J].Lishizhen Medicine and Materia Medica Research,2006,17(8):1404-1405. |
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| Authors: | CHEN Jing-min LI You-di |
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| Institution: | Guangxi Institute of Traditional Medical and Pharmaceutical Sciences ,Nanning 530022, China |
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| Abstract: | Objective To study the pharmacological actions of Jinyingzi on acute experimental serum sickness nephritis model rats. Methods The rat model of acute experimental serum sickness nephritis was induced by injecting serum through caudal vein. The renal function about urinary protein,serum total protein,creatinine and urinary nitrogen in model rat were studied after ig. Jinyingzi for 4 wk. Results Jinyingzi can remarkably reduced urinary protein, levels of serum creatinine and urinary nitrogen, increased serum total protein content, and alleviated the pathological injury in model rats. Conclusion Jinyingzi can lessen pathological changes of glomerulus in acute experimental serum sickness nephritis model rats, ameliorate their renal function. |
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| Keywords: | Rosa laevigata Michx Acute experimental serum sickness nephritis model Pharmacoligical actions |
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