| HLA-DRB和ACE基因与肺结核的相关性分析 |
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| 引用本文： | 时广利,胡秀玲,荣长利,张宝秋,宋长兴.HLA-DRB和ACE基因与肺结核的相关性分析[J].中国防痨通讯,2007,29(4):327-329. |
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| 作者姓名： | 时广利 胡秀玲 荣长利 张宝秋 宋长兴 |
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| 作者单位： | 北京市结核病胸部肿瘤研究所 北京 101149； |
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| 摘 要： | 目的探讨人类白细胞抗原(HLA)-DRB基因和血管紧张素转换酶(ACE)基因多态性与肺结核的相关性。方法采用聚合酶链反应-序列特异性引物法(PCR-SSP)对肺结核组和健康对照组进行HLA-DRB和ACE基因分型。结果肺结核组HLA-DRB1*15等位基因的频率显著高于对照组(P＜0.05)；复治和耐药肺结核组ACE基因的I/D基因型频率显著高于初治和无耐药组(P＜0.05)。结论HLA-DRB1*15等位基因及ACE基因的I/D基因型与肺结核密切相关。
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| 关 键 词： | HLA-DRB基因 ACE基因 结核 肺 |
| 修稿时间： | 2006年9月14日 |
Association of polymorphisms of HLA-DRB gene and ACE gene with pulmonary tuberculosis |
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| Shi Guangli,Hu Xiuling,Rong Changli,et al..Association of polymorphisms of HLA-DRB gene and ACE gene with pulmonary tuberculosis[J].The Journal of The Chinese Antituberculosis Association,2007,29(4):327-329. |
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| Authors: | Shi Guangli Hu Xiuling Rong Changli |
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| Institution: | (Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing 101149,China) |
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| Abstract: | Objective To analyze the relation of polymorphisms of HLA-DRB gene and ACE gene with pulmonary tuberculosis.Methods PCR/SSP was used to identify the HLA-DRB and ACE genotype in pulmonary tuberculosis group and control group.Results The frequency of HLA-DRB1*15 allele in pulmonary tuberculosis group was significantly higher than that in control group(P<0.05).The frequency of ACE I/D genotype in retreatment and drug-resistant pulmonary tuberculosis group was significantly higher than that in initial and drug-sensitive group(P<0.05).Conclusion The HLA-DRB1*15 allele and the I/D genotype of ACE gene were evidently associated with pulmonary tuberculosis. |
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| Keywords: | Human leukocyte antigen gene Angiotensin converting enzyme gene Pulmonary tuberculosis |
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