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| 法莫替丁口溶片的药代动力学及生物利用度 | |
| 引用本文： | ZHANG Jian-chun,张建春,邓明德,陈鼎继,蒋雪涛. 法莫替丁口溶片的药代动力学及生物利用度[J]. 中国新药杂志, 2001, 10(3): 198-200 |
| 作者姓名： | ZHANG Jian-chun 张建春 邓明德 陈鼎继 蒋雪涛 |
| 作者单位： | 1. The First Hospital of PLA, 2. 解放军第一医院, 3. 第二军医大学药学院, |
| 摘 要： | 目的研究法莫替丁口溶片在家兔体内的药代动力学过程和生物利用度。方法家兔单剂量服用法莫替丁口溶片和法莫替丁普通市售片后，用高效液相色谱法测定血药浓度。结果法莫替丁口溶片和普通市售片的AUC分别为(2687.63±461.65)和(1477.65±484.28)(ng |
| 关 键 词： | 法莫丁 口溶片 高效液相色谱法 生物利用度 药代动力学 |
| 文章编号： | 1003-3734(2001)03-0198-03 |
The pharmacokinetics andrelative bioavailability of rapid dissolving tablet of famotidine in mouth |
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| Abstract: | Objective:To study the pharmacokinetics and bioavai lability of rapid dissolving tablet of famotidine in mouth and famotidine market tablet in rabbits.Methods:Rapid dissolving tablets in mouth and m arket tablets of famotidine were single-dose orally given to rabbits.The blood levels of famotidine was determined by HPLC method.Results:The AUC ,Cmax and Tmax of rapid dissolving tablets in mouth of famotidine we re (2 687.63±461.65)(ng*h)/ml,(658.18±84.97)ng/ml and (1.29±0.23)h,and t he AUC,Cmax and Tmax of market tablet of famotidine were (1 4 77.65±484.28)(ng*h)/ml,(202.80±57.29) ng/ml and (2.85±0.54)h. Conclusion:There is significant difference (P<0.01) between the AUC of two products,and the bioavailability of rapid dissolving tablet of famot idine in mouth is 181.88%. |
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