Quel bilan d’imagerie avant une radiothérapie de rattrapage après prostatectomie radicale pour adénocarcinome prostatique ? |
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| Authors: | D Pasquier A Hugentobler P Masson |
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| Institution: | 1. Service de radiothérapie, centre Galilée, polyclinique de la Louvière, 69, rue de la Louvière, 59000 Lille, France;2. Service de médecine nucléaire, polyclinique de la Louvière, Lille, France;3. Clinique radiologique du pont St-Vaast, Douai, France;1. Mount Vernon Cancer Centre, Northwood, UK;2. St Bartholomews'' Hospital, London, UK;1. Service de radiothérapie, institut de cancérologie et d’hématologie, CHRU Morvan, 2, avenue Foch, 29200 Brest, France;2. Service de médecine nucléaire, CHRU Morvan, 2, avenue Foch, 29200 Brest, France;3. Service de radiothérapie, centre hospitalier de Cornouaille, 14bis, avenue Yves-Thépot, 29107 Quimper cedex, France;1. School of Earth and Environmental Sciences, University of Portsmouth, Burnaby Building, Burnaby Road, Portsmouth PO1 3QL, UK;2. Department of Geography and Geology, University of Copenhagen, Øster Voldgade 10, 1350 Copenhagen K, Denmark;1. Changchun University of Science & Technology, School of Chemistry and Environmental Engineering, Changchun 130022, China;2. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;1. Cancer Research Center–Instituto de Biología Celular y Molecular del Cáncer (IBMCC) of the Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca (USAL), Salamanca, Spain;2. Cytometry Service (NUCLEUS), University of Salamanca, Salamanca, Spain;3. Department of Medicine, University of Salamanca, Salamanca, Spain;4. Centro de Investigación Biomédica en Red de Cáncer (CIBER-ONC), Instituto Carlos III, Madrid, Spain;5. Instituto de Investigación Biosanitaria (IBSAL), Salamanca, Spain;6. Department of Hematology, University Hospital of Salamanca, Salamanca, Spain;7. Department of Biochemistry, University Hospital of Salamanca, Salamanca, Spain;8. Department of Pediatrics, Institute of Pediatrics and Puericulture Martagão Gesteira (IPPMG), Rio de Janeiro, Brazil;9. University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil;10. Department of Hematology, Hospital of Zamora, Zamora, Spain;11. Department of Hematology, Hospital of Palencia, Palencia, Spain;12. Department of Hematology, Hospital of Segovia, Segovia, Spain;13. Department of Hematology, Hospital of Soria, Soria, Spain;14. Department of Hematology, Hospital of Burgos, Burgos, Spain;15. Department of Hematology, Hospital of Ávila, Ávila, Spain;16. Clinica Universidad de Navarra, Applied Medical Research Center (CIMA), IDISNA, Pamplona, Spain;17. Cedars-Sinai Samuel Oschin Cancer Center, Los Angeles, CA;18. Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands |
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| Abstract: | Prostatectomy is one of the most widely used methods for treatment of adenocarcinoma of the prostate. According to anatomopathological criteria, between 10 and 40% of patients will display biochemical relapse in the absence of adjuvant radiotherapy. Anatomopathological and biochemical criteria are powerful tools for selecting patients for salvage radiotherapy. The aim of this article is to review literature on the latest progress in radiological and nuclear medicine techniques and their performance levels, in order to determine local, regional and metastatic relapses associated with the techniques and specify the radiotherapy target volume. Magnetic resonance imaging (MRI) displays the best sensitivity and specificity for examination of the prostate bed and enables simultaneous assessment of the pelvic region – thus diminishing the utility of computed tomography. The performance levels of MRI will probably continue to improve, with the use of dynamic MRI and MR spectroscopy. Despite the development of new markers like 11C and 18F choline and acetate, the sensitivity of positron emission tomography is still low. Prospective studies with an appropriate methodology are necessary for specifying the technique's value in this context. |
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