Multicentric Castleman's disease mimicking adult-onset Still's disease |
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| Authors: | Maria Marta Bianchi Javier Narváez Pilar Santo Valeria Ríos-Rodriguez Diana de la Fuente Daniel Roig-Vilaseca Joan Miquel Nolla |
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| Institution: | 1. Department of Rheumatology, Hospital Universitario de Bellvitge-IDIBELL, Barcelona, Spain;2. Unidad de Reumatología, SAP Baix Llobregat Centre, Cornellà de Llobregat, Barcelona, Spain;1. Department of Pathology and Experimental Rheumatology, Medical University of Gdańsk, Poland;2. Voivodal Rheumatology Hospital, Sopot, Poland;3. Chair and Department of Pathophysiology, Medical University of Gdańsk, Poland;1. Centro de Salud San Pablo, Sevilla, España;2. Servicio de Anatomía Patológica, Hospital Universitario Virgen del Rocío, Sevilla, España;1. St. Francis Hospital, The Heart Center, Roslyn, New York;2. State University of New York at Stony Brook, Stony Brook, New York |
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| Abstract: | Castleman's disease is a rare lymphoproliferative disorder having two types of presentation: the localized and the multicentric form. Multicentric Castleman's disease (MCD) typically presents with constitutional symptoms, generalized peripheral lymphadenopathy, hepatosplenomegaly, and laboratory markers of inflammation. Rash and arthritis may also be initial complaints of this disease. In these cases, MCD can resemble adult-onset Still's disease (AOSD), especially if the arthritis precedes other manifestations.We describe a patient with initial clinical suspicion of AOSD. Eighteen months later evidence of MCD was ascertained when the patient developed insidiously growing axillary lymphadenopathies. Despite its rarity, MCD should be borne in mind in the differential diagnosis of patients with suspicion of AOSD. |
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