Neuroprotective Effects of Kangen-karyu on Spatial Memory Impairment in an 8-Arm Radial Maze and Neuronal Death in the Hippocampal CA1 Region Induced by Repeated Cerebral Ischemia in Rats |
| |
Authors: | Fengling Pu Kyoko Motohashi Tomohiro Kaneko Yurika Tanaka Naomi Manome Keiichi Irie Jirou Takata Nobuaki Egashira Ryozo Oishi Takuya Okamoto Yasuo Sei Takako Yokozawa Kenichi Mishima Katsunori Iwasaki Michihiro Fujiwara |
| |
Affiliation: | 1. Department of Neuropharmacology, Fukuoka 814-0180, Japan;3. Laboratory of Drug Design and Drug Delivery, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan;2. Advanced Materials Institute, Fukuoka University, Fukuoka 814-0180, Japan;4. Department of Pharmacy, Kyushu University Hospital, Fukuoka 812-8582, Japan;5. Iskra Industry Co., Ltd., Tokyo 103-0027, Japan;6. Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan |
| |
Abstract: | In the present study, we investigated the neuroprotective effects of Kangen-karyu (KGK) in a repeated cerebral ischemia model (2 × 10 min, 1-h interval). A 21-day pre- and postischemic treatment with KGK (10 – 300 mg/kg) and aspirin (5 mg/kg) improved the spatial memory impairment and neuronal death in the hippocampal CA1 region induced by repeated cerebral ischemia. However, a 7-day post-ischemic treatment with KGK did not attenuate the spatial memory impairment and neuronal death in this model. To determine the mechanism of action of KGK, we investigated the effects of a 14-day pre-ischemic treatment with KGK on cerebral blood flow in the hippocampal area of the repeated cerebral ischemia model using laser Doppler flowmetry. The 14-day pre-ischemic treatment with KGK increased the cerebral blood flow during reperfusion. These results suggest that a 21-day pre- and post-ischemic treatment with KGK can protect against brain damage caused by cerebral ischemia by increasing the cerebral blood flow in the hippocampal area. |
| |
Keywords: | repeated cerebral ischemia cerebral blood flow neuronal death |
本文献已被 ScienceDirect 等数据库收录! |
|