Electric field distribution in a finite-volume head model of deep brain stimulation |
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| Authors: | Peadar F. Grant Madeleine M. Lowery |
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| Affiliation: | 1. Radiology Unit, “Sapienza” University of Rome, Sant’Andrea Hospital, Via di Grottarossa 1035, 00189, Rome, Italy;2. Gastroenterology Unit, San Filippo Neri Hospital, Via Martinotti 20, 00100, Rome, Italy;1. Image and Signal Processing Group, Leipzig University, Augustusplatz 10-11, 04109 Leipzig, Germany;4. Department of Electrical and Computer Engineering, Northeastern University, Boston, MA, USA;5. Scientific Visualization, Leipzig University, Augustusplatz 10-11, 04109 Leipzig, Germany;6. Human Cognitive and Brain Sciences, Max Planck Institute, StephanstraÃ?e 1a, 04103 Leipzig, Germany;1. Department of Clinical Neurophysiology, Georg-August-University, Göttingen, Germany;2. Department of Diagnostic and Interventional Radiology, University Clinics of Tübingen, Germany;3. Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Denmark;4. Biomedical Engineering Section, Technical University of Denmark, Kgs. Lyngby, Denmark;5. Max-Planck Institute for Biological Cybernetics, Tübingen, Germany;6. Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA;7. Center for the Developing Brain, Child Mind Institute, New York, NY 10022, USA |
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| Abstract: | This study presents a whole-head finite element model of deep brain stimulation to examine the effect of electrical grounding, the finite conducting volume of the head, and scalp, skull and cerebrospinal fluid layers. The impedance between the stimulating and reference electrodes in the whole-head model was found to lie within clinically reported values when the reference electrode was incorporated on a localized surface in the model. Incorporation of the finite volume of the head and inclusion of surrounding outer tissue layers reduced the magnitude of the electric field and activating function by approximately 20% in the region surrounding the electrode. Localized distortions of the electric field were also observed when the electrode was placed close to the skull. Under bipolar conditions the effect of the finite conducting volume was shown to be negligible. The results indicate that, for monopolar stimulation, incorporation of the finite volume and outer tissue layers can alter the magnitude of the electric field and activating function when the electrode is deep within the brain, and may further affect the shape if the electrode is close to the skull. |
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