Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats |
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| Authors: | Charlotte A. Oomen Heleen Soeters Nathalie Audureau Lisa Vermunt Felisa N. van Hasselt Erik M. M. Manders Marian Joëls Harm Krugers Paul J. Lucassen |
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| Affiliation: | (1) Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands;(2) Center for Advanced Microscopy, University of Amsterdam, Amsterdam, The Netherlands;(3) Rudolf Magnus Institute for Neurosciences, UMC Utrecht, Utrecht, The Netherlands |
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| Abstract: | Rationale Stress elicits functional and structural changes in the hippocampus. Early life stress is one of the major risk factors for stress-related pathologies like depression. Patients suffering from depression show a reduced hippocampal volume, and in women, this occurs more often when depression is preceded by childhood trauma. However, the underlying mechanisms that account for a reduced hippocampal volume are unknown. |
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