体外受精-胚胎移植周期第次对其妊娠的影响

目的 探讨体外受精－胚胎移植（IVF－ET）周期第次对其妊娠的影响。方法 回顾性分析妇性输卵管因素不孕行IVF－ET的908个周期的资料。结果 胺患者进行IVF－ET周期治疗的第1次、第2次、第3次、第4次及以上分4组，其种植率分别为17.6%、17.5%、8.7%、4.6%，经分别为41.1%、40.2%、21.1%、17.2%。进行IVF－ET周期第3次及以上的种植率肽临床妊娠率比周期第1次、第2次低，经x^2检验，有统计学意义（P＜0.001）。结论 随患者进行IVF－ET周期第次的增加，IVF－ET种植率及临床妊娠率逐渐下降，尤其是第3周期以上者更为明显。

Effects of repeated cycles of in vitro fertilization-embryo transfer on pregnanc ies

Objective To evaluate the effects of repeated cycles of in vitro fertilization and embryo transfer on pregnancies (IVF-ET).Methods 908 cycles with tubal factor infertility of IVF-ET performed in Reproductive Medicine Center of First Affiliated Hospital, Sun Yat-sen University from February 1999 to January 2001 were analyzed retrospectively.Results Implantation rates (IRS) of IVF-ET cycles 1?2?3 and 4 were 17.6%?17.5%?8.7% and 4.6% respectively.Clinical pregnancy rates ( PRs ) of IVF-ET cycles 1?2?3 and 4 were 41.1%?40.2%?21.1% and 17.2% respectively.Implantation rate and pregnancy rate of IVF-ET cycles 3 and 4 were significantly lower than IVF-ET cycles 1?2(P<0.001).Conclusion Clinical pregnancy rates and implantation rates of IVF-ET decrease significantly with the increase of IVF-ET cycle.