血液透析肾病患者GBV-C感染的分析

目的 探讨血液透析病人中GBV-C(GBV-C／HGV)感染情况及GBV-C的致病性。方法 对北京地区67例因肾功能衰竭而进行血液透析的患血清，用PCR法检测HCVRNA，GBV-C RNA和HBV DNA。同时应用ELISA法检测HBsAg和抗-HCV。结果 67例患血清GBV-C RNA的检出率为16．42％。HBV DNA的检出率为26．87％，HCV RNA的检出率为22．39％，GBV-C和HCV的感染率随透析次数的增多而增高。在单独感染GBV-C的血液透析患中未发现血清ALT或AST异常。结论 GBV-C的感染率随透析时间的延长而增高，提示血液透析可能是GBV-C的传播途径之一。未发现经血液透析获得单独GBV-C感染的血清转氨酶异常．证明GBV-C很可能不具有嗜肝致病性。

GBV-C infection in hemodialysis patients

Objective To study the prevalence of GBV-C and the clinical significance of GBV-C in hemodialysis patients. Methods Sixty-seven hemodialysis patients were enrolled in this study and HBV DNA,HCV RNA and GBV-C RNA were detected by PCR.Meantime,serum markers for hepatitis B and C were detected with commercially available enzyme-linked immunosorbent assay kits. Results The prevalence of GBV-C in 67 hemodialysis was 16.42%,and the prevalence HCV and HBV among the hemodialysis patients was 22.39% and 26.87% respectively.The detection rate of GBV-C and HCV viremias increased with duration of hemodialysis.Serum alanine aminotransferase (ALT and AST) were elevated in patients with HCV or HBV viremia but not in patients with GBV-C viremia. Conclusion The hemodialysis procedures seemed to be crucial for the transmission of GBV-C.The pathogenic effects of GBV-C on hepatitis appeared to be limited.