| 反相高效液相色谱法测定复方白氟膜剂中地塞米松磷酸钠的含量 |
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| 引用本文： | 黄雪梅,陈英,姜平川. 反相高效液相色谱法测定复方白氟膜剂中地塞米松磷酸钠的含量[J]. 中国药房, 2005, 16(7): 535-537 |
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| 作者姓名： | 黄雪梅 陈英 姜平川 |
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| 作者单位： | 1. 广西壮族自治区人民医院药剂科,南宁市,500021
2. 广西中医药研究所,南宁市,530022 |
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| 摘 要： | 目的:建立以反相高效液相色谱法测定复方白氟膜剂中地塞米松磷酸钠含量的方法。方法:色谱柱为X -TerraRP18,流动相为甲醇-0 .34 %KH2PO4 溶液-三乙胺(52∶48∶0.2) ,检测波长为242nm ,柱温为30℃,流速为0 7ml/min。结果:地塞米松磷酸钠进样量在0. 0403μg～2 016μg 范围内线性关系良好(r=0 9999 ,n=3) ,平均加样回收率为99. 85 % (RSD=3. 00 % ,n=6)。结论:本方法简便、准确、重现性好,可用于复方白氟膜剂的质量控制。
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| 关 键 词： | 反相高效液相色谱法 复方白氟膜剂 地塞米松磷酸钠 含量测定 |
| 文章编号： | 1001-0408(2005)07-0535-03 |
| 修稿时间： | 2004-08-02 |
Content Determination of Dexamethasone Sodium Phosphate in Compound Baifu Pellicles by RP - HPLC |
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| HUANG Xuemei,CHEN Ying,JIANG Pingchuan. Content Determination of Dexamethasone Sodium Phosphate in Compound Baifu Pellicles by RP - HPLC[J]. China Pharmacy, 2005, 16(7): 535-537 |
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| Authors: | HUANG Xuemei CHEN Ying JIANG Pingchuan |
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| Abstract: | OBJECTIVE:To establish a RP-HPLC method for content determination of Dexamethasone Sodium Phos-phate in Compound Baifu Pellicles.METHODS:A X-Terra RP 18 column was used,the mobile phase was Methanol-0.34%KH 2 PO 4 solution-triethylamine(52∶48∶0.2),detecting wavelength was242nm and the flow rate was0.7ml/min.RE-SULTS:Dexamethasone Sodium Phosphate was in the good linear range when the sample size was between0.0403μg～2.016μg(r=0.9999,n=3).The average recovery rate was99.85%(RSD=3.00%,n=6).CONCLUSIONS:The established method is convenient,accurate,replicable,which can be applied to quality control of Compound Baifu Pellicles. |
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| Keywords: | RP-HPLC Compound Baifu Pellicles Dexamethasone Sodium Phosphate Content determination |
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